A theoretical description relating skin penetration to the thickness of the applied medicament

Richard H. Guy; Jonathan Hadgraft

doi:10.1016/0378-5173(80)90115-5

A theoretical description relating skin penetration to the thickness of the applied medicament

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Abstract

Mathematical expressions have been derived which relate the degree of percutaneous penetration to the thickness of the applied base. The relative importance of simple physicochemical parameters is discussed and theoretical release curves provided to show the way in which optimum dosage regimens may be achieved.

Original language	English
Pages (from-to)	321-332
Number of pages	12
Journal	International Journal of Pharmaceutics
Volume	6
Issue number	3-4
DOIs	https://doi.org/10.1016/0378-5173(80)90115-5
Publication status	Published - 1980

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/0378-5173(80)90115-5

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title = "A theoretical description relating skin penetration to the thickness of the applied medicament",

abstract = "Mathematical expressions have been derived which relate the degree of percutaneous penetration to the thickness of the applied base. The relative importance of simple physicochemical parameters is discussed and theoretical release curves provided to show the way in which optimum dosage regimens may be achieved.",

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AU - Guy, Richard H.

AU - Hadgraft, Jonathan

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JO - International Journal of Pharmaceutics

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A theoretical description relating skin penetration to the thickness of the applied medicament

Abstract

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