A theoretical description of the effects of volatility and substantivity on percutaneous absorption

Richard H. Guy; Jonathan Hadgraft

doi:10.1016/0378-5173(84)90114-5

A theoretical description of the effects of volatility and substantivity on percutaneous absorption

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Abstract

Substances applied to the skin may be removed from the skin surface by evaporation, washing or simple physical abrasion. These losses may be simulated by assuming that they are zero-or first-order processes. In this paper we present theoretical equations to describe the distribution of drugs within the skin allowing for concomitant loss from the surface. The solutions to the diffusion equations show the relative contributions of the loss processes to the overall fate of the applied drug.

Original language	English
Pages (from-to)	139-147
Number of pages	9
Journal	International Journal of Pharmaceutics
Volume	18
Issue number	1-2
DOIs	https://doi.org/10.1016/0378-5173(84)90114-5
Publication status	Published - Jan 1984

Bibliographical note

Funding Information:
We thank The Wellcome Trust and the Burroughs Wellcome Fund who provided financial assistance for this work.

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/0378-5173(84)90114-5

Cite this

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title = "A theoretical description of the effects of volatility and substantivity on percutaneous absorption",

abstract = "Substances applied to the skin may be removed from the skin surface by evaporation, washing or simple physical abrasion. These losses may be simulated by assuming that they are zero-or first-order processes. In this paper we present theoretical equations to describe the distribution of drugs within the skin allowing for concomitant loss from the surface. The solutions to the diffusion equations show the relative contributions of the loss processes to the overall fate of the applied drug.",

author = "Guy, {Richard H.} and Jonathan Hadgraft",

note = "Funding Information: We thank The Wellcome Trust and the Burroughs Wellcome Fund who provided financial assistance for this work.",

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AB - Substances applied to the skin may be removed from the skin surface by evaporation, washing or simple physical abrasion. These losses may be simulated by assuming that they are zero-or first-order processes. In this paper we present theoretical equations to describe the distribution of drugs within the skin allowing for concomitant loss from the surface. The solutions to the diffusion equations show the relative contributions of the loss processes to the overall fate of the applied drug.

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A theoretical description of the effects of volatility and substantivity on percutaneous absorption

Abstract

Bibliographical note

ASJC Scopus subject areas

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