Abstract
Objective: Lifestyle (smoking, drinking alcohol) and body mass index (BMI) predictors of successful outcomes in assisted reproductive technology (ART) treatments were examined in this meta-analysis. Method: A bibliographic search was undertaken using six databases. The review was informed by PRISMA/MOOSE guidelines. Meta-analytic data were analysed using random effects models. Results: We included 77 studies examining effects of BMI, smoking and drinking alcohol. Patients with a BMI< =24.9 were significantly more likely to achieve LB/pregnancy than with BMI> =25 OR = 1.219 (95% CI:1.128–1.319, z = 4.971, p <.001; I 2 = 53.779%, p =.001). Non-smokers were significantly more likely to achieve a LB or pregnancy than smokers OR = 1.457 (95% CI:1.228–1.727, z = 4.324, p <.001; I 2 = 51.883; p =.001). Meta-regression revealed the number of embryos transferred significantly moderated the effects of smoking on ART outcomes, and there was a trend indicating primary infertility and high BMI were also significant moderators. The evidence for drinking alcohol was inconclusive due to the small number of studies. Conclusions: This meta-analysis confirms that ART treatment success can be predicted with lifestyle factors. Further, non-smokers’ relative odds of pregnancy/live birth increase as more embryos were transferred but there was a trend that the odds of pregnancy/live birth decrease with primary infertility and high BMI.
| Original language | English |
|---|---|
| Pages (from-to) | 2-18 |
| Number of pages | 17 |
| Journal | Journal of Psychosomatic Obstetrics and Gynecology |
| Volume | 40 |
| Issue number | 1 |
| Early online date | 27 Nov 2017 |
| DOIs | |
| Publication status | Published - 2019 |
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Keywords
- IVF
- Infertility
- assisted reproductive technologies
- women’s health
ASJC Scopus subject areas
- Reproductive Medicine
- Clinical Psychology
- Obstetrics and Gynaecology
- Psychiatry and Mental health
Cite this
A systematic review and meta-analysis of lifestyle and body mass index predictors of successful assisted reproductive technologies. / Purewal, Satvinder; Chapman, Sarah; Van Den Akker, Olga.
In: Journal of Psychosomatic Obstetrics and Gynecology, Vol. 40, No. 1, 2019, p. 2-18.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - A systematic review and meta-analysis of lifestyle and body mass index predictors of successful assisted reproductive technologies
AU - Purewal, Satvinder
AU - Chapman, Sarah
AU - Van Den Akker, Olga
PY - 2019
Y1 - 2019
N2 - Objective: Lifestyle (smoking, drinking alcohol) and body mass index (BMI) predictors of successful outcomes in assisted reproductive technology (ART) treatments were examined in this meta-analysis. Method: A bibliographic search was undertaken using six databases. The review was informed by PRISMA/MOOSE guidelines. Meta-analytic data were analysed using random effects models. Results: We included 77 studies examining effects of BMI, smoking and drinking alcohol. Patients with a BMI< =24.9 were significantly more likely to achieve LB/pregnancy than with BMI> =25 OR = 1.219 (95% CI:1.128–1.319, z = 4.971, p <.001; I 2 = 53.779%, p =.001). Non-smokers were significantly more likely to achieve a LB or pregnancy than smokers OR = 1.457 (95% CI:1.228–1.727, z = 4.324, p <.001; I 2 = 51.883; p =.001). Meta-regression revealed the number of embryos transferred significantly moderated the effects of smoking on ART outcomes, and there was a trend indicating primary infertility and high BMI were also significant moderators. The evidence for drinking alcohol was inconclusive due to the small number of studies. Conclusions: This meta-analysis confirms that ART treatment success can be predicted with lifestyle factors. Further, non-smokers’ relative odds of pregnancy/live birth increase as more embryos were transferred but there was a trend that the odds of pregnancy/live birth decrease with primary infertility and high BMI.
AB - Objective: Lifestyle (smoking, drinking alcohol) and body mass index (BMI) predictors of successful outcomes in assisted reproductive technology (ART) treatments were examined in this meta-analysis. Method: A bibliographic search was undertaken using six databases. The review was informed by PRISMA/MOOSE guidelines. Meta-analytic data were analysed using random effects models. Results: We included 77 studies examining effects of BMI, smoking and drinking alcohol. Patients with a BMI< =24.9 were significantly more likely to achieve LB/pregnancy than with BMI> =25 OR = 1.219 (95% CI:1.128–1.319, z = 4.971, p <.001; I 2 = 53.779%, p =.001). Non-smokers were significantly more likely to achieve a LB or pregnancy than smokers OR = 1.457 (95% CI:1.228–1.727, z = 4.324, p <.001; I 2 = 51.883; p =.001). Meta-regression revealed the number of embryos transferred significantly moderated the effects of smoking on ART outcomes, and there was a trend indicating primary infertility and high BMI were also significant moderators. The evidence for drinking alcohol was inconclusive due to the small number of studies. Conclusions: This meta-analysis confirms that ART treatment success can be predicted with lifestyle factors. Further, non-smokers’ relative odds of pregnancy/live birth increase as more embryos were transferred but there was a trend that the odds of pregnancy/live birth decrease with primary infertility and high BMI.
KW - IVF
KW - Infertility
KW - assisted reproductive technologies
KW - women’s health
UR - http://www.scopus.com/inward/record.url?scp=85035146538&partnerID=8YFLogxK
U2 - 10.1080/0167482X.2017.1403418
DO - 10.1080/0167482X.2017.1403418
M3 - Review article
VL - 40
SP - 2
EP - 18
JO - Journal of Psychosomatic Obstetrics and Gynecology
JF - Journal of Psychosomatic Obstetrics and Gynecology
SN - 0167-482X
IS - 1
ER -
