Abstract
Plant specialized metabolites have ecological functions, yet the presence of numerous uncharacterized biosynthetic genes in plant genomes suggests that many molecules remain unknown.We discovered a triterpene biosynthetic network in the roots of the small mustard plant Arabidopsis thaliana. Collectively, we have elucidated and reconstituted three divergent pathways for the biosynthesis of root triterpenes, namely thalianin (seven steps), thalianyl medium-chain fatty acid esters (three steps), and arabidin (five steps). A. thaliana mutants disrupted in the biosynthesis of these compounds have altered root microbiota. In vitro bioassays with purified compounds reveal selective growth modulation activities of pathway metabolites toward root microbiota members and their biochemical transformation and utilization by bacteria, supporting a role for this biosynthetic network in shaping an Arabidopsis-specific root microbial community.
Original language | English |
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Article number | eaau6389 |
Journal | Science |
Volume | 364 |
Issue number | 6440 |
Early online date | 10 May 2019 |
DOIs | |
Publication status | Published - 10 May 2019 |
Bibliographical note
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.ASJC Scopus subject areas
- General
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Hans-Wilhelm Nützmann
- Department of Life Sciences - Visiting Academic
Person: Honorary / Visiting Staff