A simple protocol for NMR analysis of the enantiomeric purity of chiral hydroxylamines

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Abstract

A practically simple three-component chiral derivatization protocol for determining the enantiopurity of chiral hydroxylamines by H NMR spectroscopic analysis is described, involving their treatment with 2-formylphenylboronic acid and enantiopure BINOL to afford a mixture of diastereomeric nitrono-boronate esters whose ratio is an accurate reflection of the enantiopurity of the parent hydroxylamine.
Original languageEnglish
Pages (from-to)860-863
Number of pages4
JournalOrganic Letters
Volume15
Issue number4
DOIs
Publication statusPublished - 15 Feb 2013

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