A Simple Near-Infrared Fluorescent Probe for the Detection of Peroxynitrite

Luling Wu; Xue Tian; Hai Hao Han; Jie Wang; Robin R. Groleau; Paramabhorn Tosuwan; Boontana Wannalerse; Adam C. Sedgwick; Steven D. Bull; Xiao Peng He; Tony D. James

doi:10.1002/open.201900301

A Simple Near-Infrared Fluorescent Probe for the Detection of Peroxynitrite

Luling Wu, Xue Tian, Hai Hao Han, Jie Wang, Robin R. Groleau, Paramabhorn Tosuwan, Boontana Wannalerse, Adam C. Sedgwick, Steven D. Bull, Xiao Peng He, Tony D. James

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

10 Citations (SciVal)

Abstract

Herein, we report the evaluation and synthesis of a reaction based fluorescent probe DCM-Bpin for the detection of peroxynitrite (ONOO⁻). DCM-Bpin exhibits selective fluorescence off-on response for ONOO⁻ over other reactive oxygen species, including H₂O₂. Moreover, DCM-Bpin is biocompatible and has been used to visualize exogenous ONOO⁻ in HeLa cells.

Original language	English
Pages (from-to)	1407-1409
Number of pages	3
Journal	ChemistryOpen
Volume	8
Issue number	12
Early online date	9 Dec 2019
DOIs	https://doi.org/10.1002/open.201900301
Publication status	Published - 9 Dec 2019

Keywords

boronate
fluorescence
near-infrared
peroxynitrite
probe

ASJC Scopus subject areas

Chemistry(all)

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10.1002/open.201900301Licence: CC BY

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title = "A Simple Near-Infrared Fluorescent Probe for the Detection of Peroxynitrite",

abstract = "Herein, we report the evaluation and synthesis of a reaction based fluorescent probe DCM-Bpin for the detection of peroxynitrite (ONOO−). DCM-Bpin exhibits selective fluorescence off-on response for ONOO− over other reactive oxygen species, including H2O2. Moreover, DCM-Bpin is biocompatible and has been used to visualize exogenous ONOO− in HeLa cells.",

keywords = "boronate, fluorescence, near-infrared, peroxynitrite, probe",

author = "Luling Wu and Xue Tian and Han, {Hai Hao} and Jie Wang and Groleau, {Robin R.} and Paramabhorn Tosuwan and Boontana Wannalerse and Sedgwick, {Adam C.} and Bull, {Steven D.} and He, {Xiao Peng} and James, {Tony D.}",

year = "2019",

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T1 - A Simple Near-Infrared Fluorescent Probe for the Detection of Peroxynitrite

AU - Wu, Luling

AU - Tian, Xue

AU - Han, Hai Hao

AU - Wang, Jie

AU - Groleau, Robin R.

AU - Tosuwan, Paramabhorn

AU - Wannalerse, Boontana

AU - Sedgwick, Adam C.

AU - Bull, Steven D.

AU - He, Xiao Peng

AU - James, Tony D.

PY - 2019/12/9

Y1 - 2019/12/9

N2 - Herein, we report the evaluation and synthesis of a reaction based fluorescent probe DCM-Bpin for the detection of peroxynitrite (ONOO−). DCM-Bpin exhibits selective fluorescence off-on response for ONOO− over other reactive oxygen species, including H2O2. Moreover, DCM-Bpin is biocompatible and has been used to visualize exogenous ONOO− in HeLa cells.

AB - Herein, we report the evaluation and synthesis of a reaction based fluorescent probe DCM-Bpin for the detection of peroxynitrite (ONOO−). DCM-Bpin exhibits selective fluorescence off-on response for ONOO− over other reactive oxygen species, including H2O2. Moreover, DCM-Bpin is biocompatible and has been used to visualize exogenous ONOO− in HeLa cells.

KW - boronate

KW - fluorescence

KW - near-infrared

KW - peroxynitrite

KW - probe

UR - http://www.scopus.com/inward/record.url?scp=85077378940&partnerID=8YFLogxK

U2 - 10.1002/open.201900301

DO - 10.1002/open.201900301

M3 - Article

AN - SCOPUS:85077378940

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VL - 8

SP - 1407

EP - 1409

JO - ChemistryOpen

JF - ChemistryOpen

IS - 12

ER -

A Simple Near-Infrared Fluorescent Probe for the Detection of Peroxynitrite

Abstract

Keywords

ASJC Scopus subject areas

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