A Simple Near-Infrared Fluorescent Probe for the Detection of Peroxynitrite

Luling Wu, Xue Tian, Hai Hao Han, Jie Wang, Robin R. Groleau, Paramabhorn Tosuwan, Boontana Wannalerse, Adam C. Sedgwick, Steven D. Bull, Xiao Peng He, Tony D. James

Research output: Contribution to journalArticlepeer-review

16 Citations (SciVal)

Abstract

Herein, we report the evaluation and synthesis of a reaction based fluorescent probe DCM-Bpin for the detection of peroxynitrite (ONOO). DCM-Bpin exhibits selective fluorescence off-on response for ONOO over other reactive oxygen species, including H2O2. Moreover, DCM-Bpin is biocompatible and has been used to visualize exogenous ONOO in HeLa cells.

Original languageEnglish
Pages (from-to)1407-1409
Number of pages3
JournalChemistryOpen
Volume8
Issue number12
Early online date9 Dec 2019
DOIs
Publication statusPublished - 9 Dec 2019

Funding

LW wishes to thank China Scholarship Council and the University of Bath for supporting his PhD work in the UK. We would like to thank the EPSRC and the University of Bath for funding. TDJ wishes to thank the Royal Society for a Wolfson Research Merit Award. XPH thanks the National Natural Science Foundation of China (21722801 and 21572058), the Programme of Introducing Talents of Discipline to Universities (B16017) and the Shanghai Rising-Star Program (16QA1401400). RRG wishes to thank the EPSRC Centre for Doctoral Training in Catalysis (EP/L016443/1). PT thanks the Development and Promotion of Science and Technology Talents Project (DPST) for a Royal Government of Thailand Scholarship. NMR characterisation facilities were provided by the Material and Chemical Characterisation Facility (MC2) at the University of Bath (http://go.bath.ac.uk/mc2). The EPSRC UK National Mass Spectrometry Facility at Swansea University is thanked for analyses.

Keywords

  • boronate
  • fluorescence
  • near-infrared
  • peroxynitrite
  • probe

ASJC Scopus subject areas

  • General Chemistry

Fingerprint

Dive into the research topics of 'A Simple Near-Infrared Fluorescent Probe for the Detection of Peroxynitrite'. Together they form a unique fingerprint.

Cite this