A simple 15 min exercise task improves the antibody response to pneumococcal vaccination

Kate M. Edwards, Meredith Pung, Lianne Tomfohr, John P. Campbell, Michael G. Ziegler, Mark T. Drayson, Paul J. Mills

Research output: Contribution to journalMeeting abstract

36 Citations (Scopus)

Abstract

Purpose of Study: Vaccination is a remarkable medical achievement, but many vaccines elicit poor responses, which limits efficacy. Exercise has been identified as a possible behavioural adjuvant; brief muscle damaging exercise immediately prior to vaccination enhances antibody responses with effects mostly confined to strains showing weaker control responses. Here, we tested the effect of exercise on the response to either a full or half dose of Pneumococcal (Pn) vaccine. The exercise task was developed for clinical applicability, minimizing equipment, and inducing less muscle damage. Subjects & Methods: Subjects were 132 young healthy adults (75 women; age: 22 ± 2.7years; BMI: 23 ± 3.8Kg/m2), who were randomized to one of four groups: Exercise or control task, receiving a full or half dose Pn vaccination. Prior to vaccination, exercise groups completed a 15 min task using resistance bands involving 30s of arm and shoulder exercise and 30s rest alternations. Control subjects rested quietly during this time. Antibody levels to 11 Pn strains were evaluated at baseline and 1 month. Summary of results: To assess overall effect of exercise, a multivariate ANOVA was performed with change scores (1 month-baseline) for all 11 Pn strains. A significant effect of group showed an overall greater change in antibody levels among all strains in the exercise groups. Subsequent analyses used averaged antibody values, with a repeated measures ANOVA with four groups and gender. A significant group by dose by sex interaction (p > .05) was detected, driven by women, with the exercise half dose group showing an enhanced response over the control half dose group. Discussion: The current data showed an overall effect of enhanced response among the exercise vs control groups. Specifically, this effect was found in the half dose group, with women, showing exercise-enhanced responses. The current study adds to data indicating the effectiveness of exercise as a vaccine adjuvant, particularly in weaker responses, modeled by a half dose given in young healthy adults. This evidence is important in future application of this effect in at risk groups, who are in greatest need of improvement of immune responses to vaccination.
Original languageEnglish
Pages (from-to)59-60
Number of pages2
JournalPsychosomatic Medicine
Volume73
Issue number3
Publication statusPublished - 1 Apr 2011

Fingerprint

Antibody Formation
Vaccination
Exercise
Antibodies
Young Adult
Analysis of Variance
Vaccines
Muscles
Pneumococcal Vaccines
Arm
Equipment and Supplies
Control Groups

Keywords

  • antibody
  • vaccine
  • adjuvant
  • Pneumococcus vaccine
  • exercise
  • vaccination
  • society
  • psychosomatics
  • antibody response
  • female
  • normal human
  • analysis of variance
  • shoulder
  • gender
  • control group
  • high risk population
  • immune response
  • muscle
  • muscle injury
  • arm
  • achievement

Cite this

Edwards, K. M., Pung, M., Tomfohr, L., Campbell, J. P., Ziegler, M. G., Drayson, M. T., & Mills, P. J. (2011). A simple 15 min exercise task improves the antibody response to pneumococcal vaccination. Psychosomatic Medicine, 73(3), 59-60.

A simple 15 min exercise task improves the antibody response to pneumococcal vaccination. / Edwards, Kate M.; Pung, Meredith; Tomfohr, Lianne; Campbell, John P.; Ziegler, Michael G.; Drayson, Mark T.; Mills, Paul J.

In: Psychosomatic Medicine, Vol. 73, No. 3, 01.04.2011, p. 59-60.

Research output: Contribution to journalMeeting abstract

Edwards, KM, Pung, M, Tomfohr, L, Campbell, JP, Ziegler, MG, Drayson, MT & Mills, PJ 2011, 'A simple 15 min exercise task improves the antibody response to pneumococcal vaccination', Psychosomatic Medicine, vol. 73, no. 3, pp. 59-60.
Edwards KM, Pung M, Tomfohr L, Campbell JP, Ziegler MG, Drayson MT et al. A simple 15 min exercise task improves the antibody response to pneumococcal vaccination. Psychosomatic Medicine. 2011 Apr 1;73(3):59-60.
Edwards, Kate M. ; Pung, Meredith ; Tomfohr, Lianne ; Campbell, John P. ; Ziegler, Michael G. ; Drayson, Mark T. ; Mills, Paul J. / A simple 15 min exercise task improves the antibody response to pneumococcal vaccination. In: Psychosomatic Medicine. 2011 ; Vol. 73, No. 3. pp. 59-60.
@article{015f720be6764692a7eb6726b4c71a48,
title = "A simple 15 min exercise task improves the antibody response to pneumococcal vaccination",
abstract = "Purpose of Study: Vaccination is a remarkable medical achievement, but many vaccines elicit poor responses, which limits efficacy. Exercise has been identified as a possible behavioural adjuvant; brief muscle damaging exercise immediately prior to vaccination enhances antibody responses with effects mostly confined to strains showing weaker control responses. Here, we tested the effect of exercise on the response to either a full or half dose of Pneumococcal (Pn) vaccine. The exercise task was developed for clinical applicability, minimizing equipment, and inducing less muscle damage. Subjects & Methods: Subjects were 132 young healthy adults (75 women; age: 22 ± 2.7years; BMI: 23 ± 3.8Kg/m2), who were randomized to one of four groups: Exercise or control task, receiving a full or half dose Pn vaccination. Prior to vaccination, exercise groups completed a 15 min task using resistance bands involving 30s of arm and shoulder exercise and 30s rest alternations. Control subjects rested quietly during this time. Antibody levels to 11 Pn strains were evaluated at baseline and 1 month. Summary of results: To assess overall effect of exercise, a multivariate ANOVA was performed with change scores (1 month-baseline) for all 11 Pn strains. A significant effect of group showed an overall greater change in antibody levels among all strains in the exercise groups. Subsequent analyses used averaged antibody values, with a repeated measures ANOVA with four groups and gender. A significant group by dose by sex interaction (p > .05) was detected, driven by women, with the exercise half dose group showing an enhanced response over the control half dose group. Discussion: The current data showed an overall effect of enhanced response among the exercise vs control groups. Specifically, this effect was found in the half dose group, with women, showing exercise-enhanced responses. The current study adds to data indicating the effectiveness of exercise as a vaccine adjuvant, particularly in weaker responses, modeled by a half dose given in young healthy adults. This evidence is important in future application of this effect in at risk groups, who are in greatest need of improvement of immune responses to vaccination.",
keywords = "antibody, vaccine, adjuvant, Pneumococcus vaccine, exercise, vaccination, society, psychosomatics, antibody response, female, normal human, analysis of variance, shoulder, gender, control group, high risk population, immune response, muscle, muscle injury, arm, achievement",
author = "Edwards, {Kate M.} and Meredith Pung and Lianne Tomfohr and Campbell, {John P.} and Ziegler, {Michael G.} and Drayson, {Mark T.} and Mills, {Paul J.}",
year = "2011",
month = "4",
day = "1",
language = "English",
volume = "73",
pages = "59--60",
journal = "Psychosomatic Medicine",
issn = "0033-3174",
publisher = "Lippincott Williams & Wilkins",
number = "3",

}

TY - JOUR

T1 - A simple 15 min exercise task improves the antibody response to pneumococcal vaccination

AU - Edwards, Kate M.

AU - Pung, Meredith

AU - Tomfohr, Lianne

AU - Campbell, John P.

AU - Ziegler, Michael G.

AU - Drayson, Mark T.

AU - Mills, Paul J.

PY - 2011/4/1

Y1 - 2011/4/1

N2 - Purpose of Study: Vaccination is a remarkable medical achievement, but many vaccines elicit poor responses, which limits efficacy. Exercise has been identified as a possible behavioural adjuvant; brief muscle damaging exercise immediately prior to vaccination enhances antibody responses with effects mostly confined to strains showing weaker control responses. Here, we tested the effect of exercise on the response to either a full or half dose of Pneumococcal (Pn) vaccine. The exercise task was developed for clinical applicability, minimizing equipment, and inducing less muscle damage. Subjects & Methods: Subjects were 132 young healthy adults (75 women; age: 22 ± 2.7years; BMI: 23 ± 3.8Kg/m2), who were randomized to one of four groups: Exercise or control task, receiving a full or half dose Pn vaccination. Prior to vaccination, exercise groups completed a 15 min task using resistance bands involving 30s of arm and shoulder exercise and 30s rest alternations. Control subjects rested quietly during this time. Antibody levels to 11 Pn strains were evaluated at baseline and 1 month. Summary of results: To assess overall effect of exercise, a multivariate ANOVA was performed with change scores (1 month-baseline) for all 11 Pn strains. A significant effect of group showed an overall greater change in antibody levels among all strains in the exercise groups. Subsequent analyses used averaged antibody values, with a repeated measures ANOVA with four groups and gender. A significant group by dose by sex interaction (p > .05) was detected, driven by women, with the exercise half dose group showing an enhanced response over the control half dose group. Discussion: The current data showed an overall effect of enhanced response among the exercise vs control groups. Specifically, this effect was found in the half dose group, with women, showing exercise-enhanced responses. The current study adds to data indicating the effectiveness of exercise as a vaccine adjuvant, particularly in weaker responses, modeled by a half dose given in young healthy adults. This evidence is important in future application of this effect in at risk groups, who are in greatest need of improvement of immune responses to vaccination.

AB - Purpose of Study: Vaccination is a remarkable medical achievement, but many vaccines elicit poor responses, which limits efficacy. Exercise has been identified as a possible behavioural adjuvant; brief muscle damaging exercise immediately prior to vaccination enhances antibody responses with effects mostly confined to strains showing weaker control responses. Here, we tested the effect of exercise on the response to either a full or half dose of Pneumococcal (Pn) vaccine. The exercise task was developed for clinical applicability, minimizing equipment, and inducing less muscle damage. Subjects & Methods: Subjects were 132 young healthy adults (75 women; age: 22 ± 2.7years; BMI: 23 ± 3.8Kg/m2), who were randomized to one of four groups: Exercise or control task, receiving a full or half dose Pn vaccination. Prior to vaccination, exercise groups completed a 15 min task using resistance bands involving 30s of arm and shoulder exercise and 30s rest alternations. Control subjects rested quietly during this time. Antibody levels to 11 Pn strains were evaluated at baseline and 1 month. Summary of results: To assess overall effect of exercise, a multivariate ANOVA was performed with change scores (1 month-baseline) for all 11 Pn strains. A significant effect of group showed an overall greater change in antibody levels among all strains in the exercise groups. Subsequent analyses used averaged antibody values, with a repeated measures ANOVA with four groups and gender. A significant group by dose by sex interaction (p > .05) was detected, driven by women, with the exercise half dose group showing an enhanced response over the control half dose group. Discussion: The current data showed an overall effect of enhanced response among the exercise vs control groups. Specifically, this effect was found in the half dose group, with women, showing exercise-enhanced responses. The current study adds to data indicating the effectiveness of exercise as a vaccine adjuvant, particularly in weaker responses, modeled by a half dose given in young healthy adults. This evidence is important in future application of this effect in at risk groups, who are in greatest need of improvement of immune responses to vaccination.

KW - antibody

KW - vaccine

KW - adjuvant

KW - Pneumococcus vaccine

KW - exercise

KW - vaccination

KW - society

KW - psychosomatics

KW - antibody response

KW - female

KW - normal human

KW - analysis of variance

KW - shoulder

KW - gender

KW - control group

KW - high risk population

KW - immune response

KW - muscle

KW - muscle injury

KW - arm

KW - achievement

M3 - Meeting abstract

VL - 73

SP - 59

EP - 60

JO - Psychosomatic Medicine

JF - Psychosomatic Medicine

SN - 0033-3174

IS - 3

ER -