A selective hydration of nitriles catalysed by a Pd(OAc)2-based system in water

Daniel Sanz Sharley; Jonathan Williams

doi:10.1016/j.tetlet.2017.09.034

A selective hydration of nitriles catalysed by a Pd(OAc)₂-based system in water

Daniel Sanz Sharley, Jonathan Williams

Research output: Contribution to journal › Article

30 Citations (SciVal)

457 Downloads (Pure)

Abstract

In situ formation of a [Pd(OAc)₂bipy] (bipy = 2,2′-bipyridyl) complex in water selectively catalyses the hydration of a wide range of organonitriles at 70 °C. Catalyst loadings of 5 mol% afford primary amide products in excellent yields in the absence of hydration-promoting additives such as oximes and hydroxylamines.

Original language	English
Pages (from-to)	4090
Number of pages	4093
Journal	Tetrahedron Letters
Volume	58
Issue number	43
DOIs	https://doi.org/10.1016/j.tetlet.2017.09.034
Publication status	Published - 14 Sept 2017

Access to Document

10.1016/j.tetlet.2017.09.034

Tet Lett Accepted ManuscriptAccepted author manuscript, 536 KBLicence: CC BY-NC-ND

Cite this

@article{ef373cb10ddb4917840582efb3b31732,

title = "A selective hydration of nitriles catalysed by a Pd(OAc)2-based system in water",

abstract = "In situ formation of a [Pd(OAc)2bipy] (bipy = 2,2′-bipyridyl) complex in water selectively catalyses the hydration of a wide range of organonitriles at 70 °C. Catalyst loadings of 5 mol\% afford primary amide products in excellent yields in the absence of hydration-promoting additives such as oximes and hydroxylamines.",

author = "\{Sanz Sharley\}, Daniel and Jonathan Williams",

year = "2017",

month = sep,

day = "14",

doi = "10.1016/j.tetlet.2017.09.034",

language = "English",

volume = "58",

pages = "4090",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier",

number = "43",

}

TY - JOUR

T1 - A selective hydration of nitriles catalysed by a Pd(OAc)2-based system in water

AU - Sanz Sharley, Daniel

AU - Williams, Jonathan

PY - 2017/9/14

Y1 - 2017/9/14

N2 - In situ formation of a [Pd(OAc)2bipy] (bipy = 2,2′-bipyridyl) complex in water selectively catalyses the hydration of a wide range of organonitriles at 70 °C. Catalyst loadings of 5 mol% afford primary amide products in excellent yields in the absence of hydration-promoting additives such as oximes and hydroxylamines.

AB - In situ formation of a [Pd(OAc)2bipy] (bipy = 2,2′-bipyridyl) complex in water selectively catalyses the hydration of a wide range of organonitriles at 70 °C. Catalyst loadings of 5 mol% afford primary amide products in excellent yields in the absence of hydration-promoting additives such as oximes and hydroxylamines.

UR - https://doi.org/10.1016/j.tetlet.2017.09.034

UR - https://www.scopus.com/pages/publications/85029719505

U2 - 10.1016/j.tetlet.2017.09.034

DO - 10.1016/j.tetlet.2017.09.034

M3 - Article

SN - 0040-4039

VL - 58

SP - 4090

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 43

ER -

A selective hydration of nitriles catalysed by a Pd(OAc)₂-based system in water

Abstract

Access to Document

Other files and links

Fingerprint

Avance NEO 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (1South)

Electrospray Time-of-Flight Mass Spectrometer (Open-Access)

Propulse 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (1South)

Cite this

A selective hydration of nitriles catalysed by a Pd(OAc)2-based system in water

Abstract

Access to Document

Other files and links

Fingerprint

Equipment

Avance NEO 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (1South)

Electrospray Time-of-Flight Mass Spectrometer (Open-Access)

Propulse 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (1South)

Cite this

A selective hydration of nitriles catalysed by a Pd(OAc)₂-based system in water