A selective hydration of nitriles catalysed by a Pd(OAc)2-based system in water

Daniel Sanz Sharley; Jonathan Williams

doi:10.1016/j.tetlet.2017.09.034

A selective hydration of nitriles catalysed by a Pd(OAc)₂-based system in water

Daniel Sanz Sharley, Jonathan Williams

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Abstract

In situ formation of a [Pd(OAc)₂bipy] (bipy = 2,2′-bipyridyl) complex in water selectively catalyses the hydration of a wide range of organonitriles at 70 °C. Catalyst loadings of 5 mol% afford primary amide products in excellent yields in the absence of hydration-promoting additives such as oximes and hydroxylamines.

Original language	English
Pages (from-to)	4090
Number of pages	4093
Journal	Tetrahedron Letters
Volume	58
Issue number	43
DOIs	https://doi.org/10.1016/j.tetlet.2017.09.034
Publication status	Published - 14 Sept 2017

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10.1016/j.tetlet.2017.09.034

Tet Lett Accepted ManuscriptAccepted author manuscript, 536 KBLicence: CC BY-NC-ND

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title = "A selective hydration of nitriles catalysed by a Pd(OAc)2-based system in water",

abstract = "In situ formation of a [Pd(OAc)2bipy] (bipy = 2,2′-bipyridyl) complex in water selectively catalyses the hydration of a wide range of organonitriles at 70 °C. Catalyst loadings of 5 mol% afford primary amide products in excellent yields in the absence of hydration-promoting additives such as oximes and hydroxylamines.",

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AU - Sanz Sharley, Daniel

AU - Williams, Jonathan

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N2 - In situ formation of a [Pd(OAc)2bipy] (bipy = 2,2′-bipyridyl) complex in water selectively catalyses the hydration of a wide range of organonitriles at 70 °C. Catalyst loadings of 5 mol% afford primary amide products in excellent yields in the absence of hydration-promoting additives such as oximes and hydroxylamines.

AB - In situ formation of a [Pd(OAc)2bipy] (bipy = 2,2′-bipyridyl) complex in water selectively catalyses the hydration of a wide range of organonitriles at 70 °C. Catalyst loadings of 5 mol% afford primary amide products in excellent yields in the absence of hydration-promoting additives such as oximes and hydroxylamines.

UR - https://doi.org/10.1016/j.tetlet.2017.09.034

U2 - 10.1016/j.tetlet.2017.09.034

DO - 10.1016/j.tetlet.2017.09.034

M3 - Article

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VL - 58

SP - 4090

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 43

ER -

A selective hydration of nitriles catalysed by a Pd(OAc)₂-based system in water

Abstract

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A selective hydration of nitriles catalysed by a Pd(OAc)2-based system in water

Abstract

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Avance NEO 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (1South)

Electrospray Time-of-Flight Mass Spectrometer (Open-Access)

Propulse 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (1South)

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A selective hydration of nitriles catalysed by a Pd(OAc)₂-based system in water