A selective hydration of nitriles catalysed by a Pd(OAc)2-based system in water

Daniel Sanz Sharley, Jonathan Williams

Research output: Contribution to journalArticle

8 Citations (Scopus)
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Abstract

In situ formation of a [Pd(OAc)2bipy] (bipy = 2,2′-bipyridyl) complex in water selectively catalyses the hydration of a wide range of organonitriles at 70 °C. Catalyst loadings of 5 mol% afford primary amide products in excellent yields in the absence of hydration-promoting additives such as oximes and hydroxylamines.
Original languageEnglish
Pages (from-to)4090
Number of pages4093
JournalTetrahedron Letters
Volume58
Issue number43
DOIs
Publication statusPublished - 14 Sep 2017

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