In situ formation of a [Pd(OAc)2bipy] (bipy = 2,2′-bipyridyl) complex in water selectively catalyses the hydration of a wide range of organonitriles at 70 °C. Catalyst loadings of 5 mol% afford primary amide products in excellent yields in the absence of hydration-promoting additives such as oximes and hydroxylamines.
Sanz Sharley, D., & Williams, J. (2017). A selective hydration of nitriles catalysed by a Pd(OAc)2-based system in water. Tetrahedron Letters, 58(43), 4090. https://doi.org/10.1016/j.tetlet.2017.09.034