A Selective Deprotection Strategy for the Construction of trans-2-Aminocyclopropanecarboxylic Acid Derived Peptides

Thomas Boddaert, James E. Taylor, Steven D. Bull, David J. Aitken

Research output: Contribution to journalArticle

Abstract

A procedure allowing access to unprecedented tripeptides containing a trans-2-aminocyclopropanecarboxylic acid residue in their central position has been established. The key features of the strategy are the use of a masked trans-2-aminocyclopropanecarboxylic acid monomer equivalent for C-terminal coupling and full N-Boc protection of all amide groups until the final step.

LanguageEnglish
Pages100-103
Number of pages4
JournalOrganic Letters
Volume21
Issue number1
Early online date17 Dec 2018
DOIs
StatusPublished - 4 Jan 2019

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

A Selective Deprotection Strategy for the Construction of trans-2-Aminocyclopropanecarboxylic Acid Derived Peptides. / Boddaert, Thomas; Taylor, James E.; Bull, Steven D.; Aitken, David J.

In: Organic Letters, Vol. 21, No. 1, 04.01.2019, p. 100-103.

Research output: Contribution to journalArticle

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