A Selective Deprotection Strategy for the Construction of trans-2-Aminocyclopropanecarboxylic Acid Derived Peptides

Thomas Boddaert, James E. Taylor, Steven D. Bull, David J. Aitken

Research output: Contribution to journal › Article

Abstract

A procedure allowing access to unprecedented tripeptides containing a trans-2-aminocyclopropanecarboxylic acid residue in their central position has been established. The key features of the strategy are the use of a masked trans-2-aminocyclopropanecarboxylic acid monomer equivalent for C-terminal coupling and full N-Boc protection of all amide groups until the final step.

LanguageEnglish
Pages100-103
Number of pages4
JournalOrganic Letters
Volume21
Issue number1
Early online date17 Dec 2018
DOIs
StatusPublished - 4 Jan 2019

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

A Selective Deprotection Strategy for the Construction of trans-2-Aminocyclopropanecarboxylic Acid Derived Peptides. / Boddaert, Thomas; Taylor, James E.; Bull, Steven D.; Aitken, David J.

In: Organic Letters, Vol. 21, No. 1, 04.01.2019, p. 100-103.

Research output: Contribution to journal › Article

Boddaert, T, Taylor, JE, Bull, SD & Aitken, DJ 2019, 'A Selective Deprotection Strategy for the Construction of trans-2-Aminocyclopropanecarboxylic Acid Derived Peptides' Organic Letters, vol. 21, no. 1, pp. 100-103. https://doi.org/10.1021/acs.orglett.8b03533
Boddaert T, Taylor JE, Bull SD, Aitken DJ. A Selective Deprotection Strategy for the Construction of trans-2-Aminocyclopropanecarboxylic Acid Derived Peptides. Organic Letters. 2019 Jan 4;21(1):100-103. https://doi.org/10.1021/acs.orglett.8b03533
Boddaert, Thomas ; Taylor, James E. ; Bull, Steven D. ; Aitken, David J. / A Selective Deprotection Strategy for the Construction of trans-2-Aminocyclopropanecarboxylic Acid Derived Peptides. In: Organic Letters. 2019 ; Vol. 21, No. 1. pp. 100-103.
@article{93467d73c8e24dbc87fe8ee01420c85a,
title = "A Selective Deprotection Strategy for the Construction of trans-2-Aminocyclopropanecarboxylic Acid Derived Peptides",
abstract = "A procedure allowing access to unprecedented tripeptides containing a trans-2-aminocyclopropanecarboxylic acid residue in their central position has been established. The key features of the strategy are the use of a masked trans-2-aminocyclopropanecarboxylic acid monomer equivalent for C-terminal coupling and full N-Boc protection of all amide groups until the final step.",
author = "Thomas Boddaert and Taylor, {James E.} and Bull, {Steven D.} and Aitken, {David J.}",
year = "2019",
month = "1",
day = "4",
doi = "10.1021/acs.orglett.8b03533",
language = "English",
volume = "21",
pages = "100--103",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "1",

}

TY - JOUR

T1 - A Selective Deprotection Strategy for the Construction of trans-2-Aminocyclopropanecarboxylic Acid Derived Peptides

AU - Boddaert, Thomas

AU - Taylor, James E.

AU - Bull, Steven D.

AU - Aitken, David J.

PY - 2019/1/4

Y1 - 2019/1/4

N2 - A procedure allowing access to unprecedented tripeptides containing a trans-2-aminocyclopropanecarboxylic acid residue in their central position has been established. The key features of the strategy are the use of a masked trans-2-aminocyclopropanecarboxylic acid monomer equivalent for C-terminal coupling and full N-Boc protection of all amide groups until the final step.

AB - A procedure allowing access to unprecedented tripeptides containing a trans-2-aminocyclopropanecarboxylic acid residue in their central position has been established. The key features of the strategy are the use of a masked trans-2-aminocyclopropanecarboxylic acid monomer equivalent for C-terminal coupling and full N-Boc protection of all amide groups until the final step.

UR - http://www.scopus.com/inward/record.url?scp=85059631123&partnerID=8YFLogxK

U2 - 10.1021/acs.orglett.8b03533

DO - 10.1021/acs.orglett.8b03533

M3 - Article

VL - 21

SP - 100

EP - 103

JO - Organic Letters

T2 - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 1

ER -

Access to Document