A search for quantitative trait loci exhibiting imprinting effects on mouse mandible size and shape

L J Leamy, C P Klingenberg, E Sherratt, J B Wolf, J M Cheverud

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Genomic imprinting refers to the pattern of monoallelic parent-of-origin-dependent gene expression where one of the two alleles at a locus is expressed and the other silenced. Although some genes in mice are known to be imprinted, the true scope of imprinting and its impact on the genetic architecture of a wide range of morphometric traits is mostly unknown. We therefore searched for quantitative trait loci (QTL) exhibiting imprinting effects on mandible size and shape traits in a large F3 population of mice originating from an intercross of the LG/J (Large) and SM/J (Small) inbred strains. We discovered a total of 51 QTL affecting mandible size and shape, 6 of which exhibited differences between reciprocal heterozygotes, the usual signature of imprinting effects. However, our analysis showed that only one of these QTL (affecting mandible size) exhibited a pattern consistent with true imprinting effects, whereas reciprocal heterozygote differences in the other five all were due to maternal genetic effects. We concluded that genomic imprinting has a negligible effect on these specific morphometric traits, and that maternal genetic effects may account for many of the previously reported instances of apparent genomic imprinting.
Original languageEnglish
Pages (from-to)518-526
Number of pages9
JournalHeredity
Volume101
Issue number6
DOIs
Publication statusPublished - Aug 2008

Fingerprint

Genomic Imprinting
Quantitative Trait Loci
Mandible
Heterozygote
Alleles
Gene Expression
Population
Genes
Maternal Inheritance

Cite this

A search for quantitative trait loci exhibiting imprinting effects on mouse mandible size and shape. / Leamy, L J; Klingenberg, C P; Sherratt, E; Wolf, J B; Cheverud, J M.

In: Heredity, Vol. 101, No. 6, 08.2008, p. 518-526.

Research output: Contribution to journalArticle

Leamy, L J ; Klingenberg, C P ; Sherratt, E ; Wolf, J B ; Cheverud, J M. / A search for quantitative trait loci exhibiting imprinting effects on mouse mandible size and shape. In: Heredity. 2008 ; Vol. 101, No. 6. pp. 518-526.
@article{b53649396c394d7188c6504c7a63082e,
title = "A search for quantitative trait loci exhibiting imprinting effects on mouse mandible size and shape",
abstract = "Genomic imprinting refers to the pattern of monoallelic parent-of-origin-dependent gene expression where one of the two alleles at a locus is expressed and the other silenced. Although some genes in mice are known to be imprinted, the true scope of imprinting and its impact on the genetic architecture of a wide range of morphometric traits is mostly unknown. We therefore searched for quantitative trait loci (QTL) exhibiting imprinting effects on mandible size and shape traits in a large F3 population of mice originating from an intercross of the LG/J (Large) and SM/J (Small) inbred strains. We discovered a total of 51 QTL affecting mandible size and shape, 6 of which exhibited differences between reciprocal heterozygotes, the usual signature of imprinting effects. However, our analysis showed that only one of these QTL (affecting mandible size) exhibited a pattern consistent with true imprinting effects, whereas reciprocal heterozygote differences in the other five all were due to maternal genetic effects. We concluded that genomic imprinting has a negligible effect on these specific morphometric traits, and that maternal genetic effects may account for many of the previously reported instances of apparent genomic imprinting.",
author = "Leamy, {L J} and Klingenberg, {C P} and E Sherratt and Wolf, {J B} and Cheverud, {J M}",
year = "2008",
month = "8",
doi = "10.1038/hdy.2008.79",
language = "English",
volume = "101",
pages = "518--526",
journal = "Heredity",
issn = "0018-067X",
publisher = "Nature Research",
number = "6",

}

TY - JOUR

T1 - A search for quantitative trait loci exhibiting imprinting effects on mouse mandible size and shape

AU - Leamy, L J

AU - Klingenberg, C P

AU - Sherratt, E

AU - Wolf, J B

AU - Cheverud, J M

PY - 2008/8

Y1 - 2008/8

N2 - Genomic imprinting refers to the pattern of monoallelic parent-of-origin-dependent gene expression where one of the two alleles at a locus is expressed and the other silenced. Although some genes in mice are known to be imprinted, the true scope of imprinting and its impact on the genetic architecture of a wide range of morphometric traits is mostly unknown. We therefore searched for quantitative trait loci (QTL) exhibiting imprinting effects on mandible size and shape traits in a large F3 population of mice originating from an intercross of the LG/J (Large) and SM/J (Small) inbred strains. We discovered a total of 51 QTL affecting mandible size and shape, 6 of which exhibited differences between reciprocal heterozygotes, the usual signature of imprinting effects. However, our analysis showed that only one of these QTL (affecting mandible size) exhibited a pattern consistent with true imprinting effects, whereas reciprocal heterozygote differences in the other five all were due to maternal genetic effects. We concluded that genomic imprinting has a negligible effect on these specific morphometric traits, and that maternal genetic effects may account for many of the previously reported instances of apparent genomic imprinting.

AB - Genomic imprinting refers to the pattern of monoallelic parent-of-origin-dependent gene expression where one of the two alleles at a locus is expressed and the other silenced. Although some genes in mice are known to be imprinted, the true scope of imprinting and its impact on the genetic architecture of a wide range of morphometric traits is mostly unknown. We therefore searched for quantitative trait loci (QTL) exhibiting imprinting effects on mandible size and shape traits in a large F3 population of mice originating from an intercross of the LG/J (Large) and SM/J (Small) inbred strains. We discovered a total of 51 QTL affecting mandible size and shape, 6 of which exhibited differences between reciprocal heterozygotes, the usual signature of imprinting effects. However, our analysis showed that only one of these QTL (affecting mandible size) exhibited a pattern consistent with true imprinting effects, whereas reciprocal heterozygote differences in the other five all were due to maternal genetic effects. We concluded that genomic imprinting has a negligible effect on these specific morphometric traits, and that maternal genetic effects may account for many of the previously reported instances of apparent genomic imprinting.

UR - http://www.scopus.com/inward/record.url?scp=56549110640&partnerID=8YFLogxK

UR - http://dx.doi.org/10.1038/hdy.2008.79

U2 - 10.1038/hdy.2008.79

DO - 10.1038/hdy.2008.79

M3 - Article

VL - 101

SP - 518

EP - 526

JO - Heredity

JF - Heredity

SN - 0018-067X

IS - 6

ER -