A new [2+2] tetra-hydrazone macrocyclic receptor was significantly amplified in a dynamic combinatorial library upon templation with alkaline earth metal ions. After optimisation the product could be isolated in 95% yield and its interaction with ions was investigated by NMR and UV-Vis spectroscopy.
Klein, J. M., Saggiomo, V., Reck, L., McPartlin, M., Pantos, G. D., Luening, U., & Sanders, J. K. M. (2011). A remarkably flexible and selective receptor for Ba2+ amplified from a hydrazone dynamic combinatorial library. Chemical Communications, 47(12), 3371-3373. https://doi.org/10.1039/c0cc04863a