A Radical FLP Approach to C–C Coupling

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In the February issue of Cell Reports Physical Science, Melen and co-workers report the reactivity of diaryl-substituted esters with R3P/B(C6F5)3 frustrated Lewis pairs (FLPs). Although ester C–O activation occurs for all FLP systems, the use of Mes3P induces single-electron transfer to generate a [Mes3P]⋅+/[C(H)Ar2] radical ion pair. In the presence of olefins, this reactivity is harnessed in an sp2-sp3 C–C heterocoupling reaction to generate α,β-substituted olefins.

Original languageEnglish
Pages (from-to)550-551
Number of pages2
Issue number3
Early online date27 Feb 2020
Publication statusPublished - 12 Mar 2020

ASJC Scopus subject areas

  • General Chemistry
  • Biochemistry
  • Environmental Chemistry
  • General Chemical Engineering
  • Biochemistry, medical
  • Materials Chemistry


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