A prospective 6-month analysis of the naturalistic use of aripiprazole - factors predicting favourable outcome

D Taylor; J Atkinson; C Fischetti; A Sparshatt; S Jones

doi:10.1111/j.1600-0447.2007.01102.x

A prospective 6-month analysis of the naturalistic use of aripiprazole - factors predicting favourable outcome

D Taylor, J Atkinson, C Fischetti, A Sparshatt, S Jones

Department of Life Sciences

South London and Maudsley NHS Foundation Trust

Research output: Contribution to journal › Article › peer-review

12 Citations (SciVal)

Abstract

OBJECTIVE: To evaluate the effectiveness of aripiprazole in clinical practice.

METHOD: Prospective follow-up of patients consecutively prescribed aripiprazole in an acute mental health unit. Retrospective analysis of outcome from casenotes.

RESULTS: Data were available on 228 patients. Fifty-one per cent discontinued aripiprazole over 6-month follow-up. Continuation with treatment was more likely in out-patients [relative risk (RR) 1.50; 95% CI: 1.13-2.00], those never before considered for clozapine treatment (RR 1.61, 95% CI: 1.06-2.44) and older patients [RR 1.05, 95% CI: 1.01-1.09 (per 5-year increase)]. The main reason for early discontinuation was the occurrence of minor adverse effects.

CONCLUSION: Aripiprazole is effective in practice. Outcome is likely to be improved by careful patient selection and by attending to adverse effects experienced early in treatment.

Original language	English
Pages (from-to)	461-466
Number of pages	6
Journal	Acta Psychiatrica Scandinavica
Volume	116
Issue number	6
Early online date	28 Oct 2007
DOIs	https://doi.org/10.1111/j.1600-0447.2007.01102.x
Publication status	Published - 31 Dec 2007

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Antipsychotic Agents/therapeutic use
Aripiprazole
Female
Humans
Male
Middle Aged
Piperazines/therapeutic use
Prospective Studies
Quinolones/therapeutic use
Retrospective Studies
Schizophrenia/diagnosis
Time Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1600-0447.2007.01102.x

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title = "A prospective 6-month analysis of the naturalistic use of aripiprazole - factors predicting favourable outcome",

abstract = "OBJECTIVE: To evaluate the effectiveness of aripiprazole in clinical practice.METHOD: Prospective follow-up of patients consecutively prescribed aripiprazole in an acute mental health unit. Retrospective analysis of outcome from casenotes.RESULTS: Data were available on 228 patients. Fifty-one per cent discontinued aripiprazole over 6-month follow-up. Continuation with treatment was more likely in out-patients [relative risk (RR) 1.50; 95\% CI: 1.13-2.00], those never before considered for clozapine treatment (RR 1.61, 95\% CI: 1.06-2.44) and older patients [RR 1.05, 95\% CI: 1.01-1.09 (per 5-year increase)]. The main reason for early discontinuation was the occurrence of minor adverse effects.CONCLUSION: Aripiprazole is effective in practice. Outcome is likely to be improved by careful patient selection and by attending to adverse effects experienced early in treatment.",

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author = "D Taylor and J Atkinson and C Fischetti and A Sparshatt and S Jones",

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T1 - A prospective 6-month analysis of the naturalistic use of aripiprazole - factors predicting favourable outcome

AU - Taylor, D

AU - Atkinson, J

AU - Fischetti, C

AU - Sparshatt, A

AU - Jones, S

PY - 2007/12/31

Y1 - 2007/12/31

N2 - OBJECTIVE: To evaluate the effectiveness of aripiprazole in clinical practice.METHOD: Prospective follow-up of patients consecutively prescribed aripiprazole in an acute mental health unit. Retrospective analysis of outcome from casenotes.RESULTS: Data were available on 228 patients. Fifty-one per cent discontinued aripiprazole over 6-month follow-up. Continuation with treatment was more likely in out-patients [relative risk (RR) 1.50; 95% CI: 1.13-2.00], those never before considered for clozapine treatment (RR 1.61, 95% CI: 1.06-2.44) and older patients [RR 1.05, 95% CI: 1.01-1.09 (per 5-year increase)]. The main reason for early discontinuation was the occurrence of minor adverse effects.CONCLUSION: Aripiprazole is effective in practice. Outcome is likely to be improved by careful patient selection and by attending to adverse effects experienced early in treatment.

AB - OBJECTIVE: To evaluate the effectiveness of aripiprazole in clinical practice.METHOD: Prospective follow-up of patients consecutively prescribed aripiprazole in an acute mental health unit. Retrospective analysis of outcome from casenotes.RESULTS: Data were available on 228 patients. Fifty-one per cent discontinued aripiprazole over 6-month follow-up. Continuation with treatment was more likely in out-patients [relative risk (RR) 1.50; 95% CI: 1.13-2.00], those never before considered for clozapine treatment (RR 1.61, 95% CI: 1.06-2.44) and older patients [RR 1.05, 95% CI: 1.01-1.09 (per 5-year increase)]. The main reason for early discontinuation was the occurrence of minor adverse effects.CONCLUSION: Aripiprazole is effective in practice. Outcome is likely to be improved by careful patient selection and by attending to adverse effects experienced early in treatment.

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KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Antipsychotic Agents/therapeutic use

KW - Aripiprazole

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Piperazines/therapeutic use

KW - Prospective Studies

KW - Quinolones/therapeutic use

KW - Retrospective Studies

KW - Schizophrenia/diagnosis

KW - Time Factors

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DO - 10.1111/j.1600-0447.2007.01102.x

M3 - Article

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SN - 0001-690X

VL - 116

SP - 461

EP - 466

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

IS - 6

ER -

A prospective 6-month analysis of the naturalistic use of aripiprazole - factors predicting favourable outcome

Abstract

Keywords

UN SDGs

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