A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders

Marta Di Forti; Benjamin W. Bond; Edoardo Spinazzola; Giulia Trotta; Jodie Lynn; Richard Malkin; Naba Kamran Siddiqui; Sultan Demir; Titilayomi Opadokun; Perry B.M. Leung; Zhikun Li; Andrea Quattrone; Gabriella Baxter; Elizabeth Appiah-Kusi; Tom P. Freeman; Hannah Walsh; Tommaso Squeri; Daria Semikina; Felicity Amberson-Jones; Isabelle Austin-Zimmerman; Tim Meynen; Diego Quattrone; Robin M. Murray

doi:10.1192/bjo.2024.782

A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders

Marta Di Forti, Benjamin W. Bond, Edoardo Spinazzola, Giulia Trotta, Jodie Lynn, Richard Malkin, Naba Kamran Siddiqui, Sultan Demir, Titilayomi Opadokun, Perry B.M. Leung, Zhikun Li, Andrea Quattrone, Gabriella Baxter, Elizabeth Appiah-Kusi, Tom P. Freeman, Hannah Walsh, Tommaso Squeri, Daria Semikina, Felicity Amberson-Jones, Isabelle Austin-ZimmermanTim Meynen, Diego Quattrone, Robin M. Murray

Research output: Contribution to journal › Article › peer-review

Abstract

Background Cannabis use severely affects the outcome of people with psychotic disorders, yet there is a lack of treatments. To address this, in 2019 the National Health Service (NHS) Cannabis Clinic for Psychosis (CCP) was developed to support adults suffering from psychosis to reduce and/or stop their cannabis use. Aims Examine outcome data from the first 46 individuals to complete the CCP's intervention. Method The sample (N = 46) consisted of adults (aged ≥ 18) with psychosis under the care of the South London and Maudsley NHS Foundation Trust, referred to the CCP between January 2020 and February 2023, who completed their intervention by September 2023. Clinical and functional measures were collected before (T0) and after (T1) the CCP intervention (one-to-one sessions and peer group attendance). Primary outcomes were changes in the Cannabis Use Disorders Identification Test-Revised (CUDIT-R) score and pattern of cannabis use. Secondary outcomes included T0-T1 changes in measures of delusions, paranoia, depression, anxiety and functioning. Results A reduction in the mean CUDIT-R score was observed between T0 (mean difference = 17.10, 95% CI = 15.54-18.67) and T1, with 73.91% of participants achieving abstinence and 26.09% reducing the frequency and potency of their use. Significant improvements in all clinical and functional outcomes were observed, with 90.70% being in work or education at T1 compared with 8.70% at T0. The variance in CUDIT-R scores explained between 34 and 64% of the variance in our secondary measures. Conclusions The CCP intervention is a feasible strategy to support cannabis use cessation/reduction and improve clinical and functional outcomes of people with psychotic disorders.

Original language	English
Article number	e1
Pages (from-to)	1-8
Journal	BJPsych Open
Volume	11
Issue number	1
DOIs	https://doi.org/10.1192/bjo.2024.782
Publication status	Published - 12 Dec 2024

Data Availability Statement

The data that support the findings of this study are part of a clinical service evaluation and therefore are available from the corresponding author M.D.F. upon reasonable request.

Funding

The Maudsley Charity https://maudsleycharity.org; Biomedical Research Centre, South London and Maudsley NHS Foundation Trust and the Medical Research Council.

Keywords

Cannabis use
cessation
personalised
psychosis
psychosocial interventions

ASJC Scopus subject areas

Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1192/bjo.2024.782Licence: CC BY

Cite this

Di Forti, M., Bond, B. W., Spinazzola, E., Trotta, G., Lynn, J., Malkin, R., Kamran Siddiqui, N., Demir, S., Opadokun, T., Leung, P. B. M., Li, Z., Quattrone, A., Baxter, G., Appiah-Kusi, E., Freeman, T. P., Walsh, H., Squeri, T., Semikina, D., Amberson-Jones, F., ... Murray, R. M. (2024). A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders. BJPsych Open, 11(1), 1-8. Article e1. https://doi.org/10.1192/bjo.2024.782

Di Forti, M, Bond, BW, Spinazzola, E, Trotta, G, Lynn, J, Malkin, R, Kamran Siddiqui, N, Demir, S, Opadokun, T, Leung, PBM, Li, Z, Quattrone, A, Baxter, G, Appiah-Kusi, E, Freeman, TP, Walsh, H, Squeri, T, Semikina, D, Amberson-Jones, F, Austin-Zimmerman, I, Meynen, T, Quattrone, D & Murray, RM 2024, 'A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders', BJPsych Open, vol. 11, no. 1, e1, pp. 1-8. https://doi.org/10.1192/bjo.2024.782

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abstract = "Background Cannabis use severely affects the outcome of people with psychotic disorders, yet there is a lack of treatments. To address this, in 2019 the National Health Service (NHS) Cannabis Clinic for Psychosis (CCP) was developed to support adults suffering from psychosis to reduce and/or stop their cannabis use. Aims Examine outcome data from the first 46 individuals to complete the CCP's intervention. Method The sample (N = 46) consisted of adults (aged ≥ 18) with psychosis under the care of the South London and Maudsley NHS Foundation Trust, referred to the CCP between January 2020 and February 2023, who completed their intervention by September 2023. Clinical and functional measures were collected before (T0) and after (T1) the CCP intervention (one-to-one sessions and peer group attendance). Primary outcomes were changes in the Cannabis Use Disorders Identification Test-Revised (CUDIT-R) score and pattern of cannabis use. Secondary outcomes included T0-T1 changes in measures of delusions, paranoia, depression, anxiety and functioning. Results A reduction in the mean CUDIT-R score was observed between T0 (mean difference = 17.10, 95% CI = 15.54-18.67) and T1, with 73.91% of participants achieving abstinence and 26.09% reducing the frequency and potency of their use. Significant improvements in all clinical and functional outcomes were observed, with 90.70% being in work or education at T1 compared with 8.70% at T0. The variance in CUDIT-R scores explained between 34 and 64% of the variance in our secondary measures. Conclusions The CCP intervention is a feasible strategy to support cannabis use cessation/reduction and improve clinical and functional outcomes of people with psychotic disorders.",

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AU - Bond, Benjamin W.

AU - Spinazzola, Edoardo

AU - Trotta, Giulia

AU - Lynn, Jodie

AU - Malkin, Richard

AU - Kamran Siddiqui, Naba

AU - Demir, Sultan

AU - Opadokun, Titilayomi

AU - Leung, Perry B.M.

AU - Li, Zhikun

AU - Quattrone, Andrea

AU - Baxter, Gabriella

AU - Appiah-Kusi, Elizabeth

AU - Freeman, Tom P.

AU - Walsh, Hannah

AU - Squeri, Tommaso

AU - Semikina, Daria

AU - Amberson-Jones, Felicity

AU - Austin-Zimmerman, Isabelle

AU - Meynen, Tim

AU - Quattrone, Diego

AU - Murray, Robin M.

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N2 - Background Cannabis use severely affects the outcome of people with psychotic disorders, yet there is a lack of treatments. To address this, in 2019 the National Health Service (NHS) Cannabis Clinic for Psychosis (CCP) was developed to support adults suffering from psychosis to reduce and/or stop their cannabis use. Aims Examine outcome data from the first 46 individuals to complete the CCP's intervention. Method The sample (N = 46) consisted of adults (aged ≥ 18) with psychosis under the care of the South London and Maudsley NHS Foundation Trust, referred to the CCP between January 2020 and February 2023, who completed their intervention by September 2023. Clinical and functional measures were collected before (T0) and after (T1) the CCP intervention (one-to-one sessions and peer group attendance). Primary outcomes were changes in the Cannabis Use Disorders Identification Test-Revised (CUDIT-R) score and pattern of cannabis use. Secondary outcomes included T0-T1 changes in measures of delusions, paranoia, depression, anxiety and functioning. Results A reduction in the mean CUDIT-R score was observed between T0 (mean difference = 17.10, 95% CI = 15.54-18.67) and T1, with 73.91% of participants achieving abstinence and 26.09% reducing the frequency and potency of their use. Significant improvements in all clinical and functional outcomes were observed, with 90.70% being in work or education at T1 compared with 8.70% at T0. The variance in CUDIT-R scores explained between 34 and 64% of the variance in our secondary measures. Conclusions The CCP intervention is a feasible strategy to support cannabis use cessation/reduction and improve clinical and functional outcomes of people with psychotic disorders.

AB - Background Cannabis use severely affects the outcome of people with psychotic disorders, yet there is a lack of treatments. To address this, in 2019 the National Health Service (NHS) Cannabis Clinic for Psychosis (CCP) was developed to support adults suffering from psychosis to reduce and/or stop their cannabis use. Aims Examine outcome data from the first 46 individuals to complete the CCP's intervention. Method The sample (N = 46) consisted of adults (aged ≥ 18) with psychosis under the care of the South London and Maudsley NHS Foundation Trust, referred to the CCP between January 2020 and February 2023, who completed their intervention by September 2023. Clinical and functional measures were collected before (T0) and after (T1) the CCP intervention (one-to-one sessions and peer group attendance). Primary outcomes were changes in the Cannabis Use Disorders Identification Test-Revised (CUDIT-R) score and pattern of cannabis use. Secondary outcomes included T0-T1 changes in measures of delusions, paranoia, depression, anxiety and functioning. Results A reduction in the mean CUDIT-R score was observed between T0 (mean difference = 17.10, 95% CI = 15.54-18.67) and T1, with 73.91% of participants achieving abstinence and 26.09% reducing the frequency and potency of their use. Significant improvements in all clinical and functional outcomes were observed, with 90.70% being in work or education at T1 compared with 8.70% at T0. The variance in CUDIT-R scores explained between 34 and 64% of the variance in our secondary measures. Conclusions The CCP intervention is a feasible strategy to support cannabis use cessation/reduction and improve clinical and functional outcomes of people with psychotic disorders.

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A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders

Abstract

Data Availability Statement

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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