A preliminary study of size reduction of powders in a single-vessel pharmaceutical processor

Stuart A MacGregor, Linda B Newnes, M Li, J N Staniforth, M J Tobyn, G R Kay, M D Horrill, R C Lamming, D W Hajee, D Wong, T Page

Research output: Contribution to journalArticle

Abstract

The size reduction performance of a pneumatically driven single-vessel pharmaceutical processor is described. Two materials were considered, namely commercially available granular lactose (CAGL) and high-speed mixer granulator lactose (HSMGL). In both cases there is an initial phase in which the particle diameter is reduced rapidly. The rate at which the size reduction decreases is reduced with time. The final particle diameter was found to be dependent on the material being processed. In the case of CAGL, the minimum size achieved was 150 mu m, while in the case of the HSMGL the final particle diameter was 100 mu m
Original languageEnglish
Pages (from-to)251-253
Number of pages3
JournalProceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture
Volume214
Issue number3
Publication statusPublished - 2000

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Granulators
Drug products
Powders

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A preliminary study of size reduction of powders in a single-vessel pharmaceutical processor. / MacGregor, Stuart A; Newnes, Linda B; Li, M; Staniforth, J N; Tobyn, M J; Kay, G R; Horrill, M D; Lamming, R C; Hajee, D W; Wong, D; Page, T.

In: Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture, Vol. 214, No. 3, 2000, p. 251-253.

Research output: Contribution to journalArticle

MacGregor, SA, Newnes, LB, Li, M, Staniforth, JN, Tobyn, MJ, Kay, GR, Horrill, MD, Lamming, RC, Hajee, DW, Wong, D & Page, T 2000, 'A preliminary study of size reduction of powders in a single-vessel pharmaceutical processor', Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture, vol. 214, no. 3, pp. 251-253.
MacGregor, Stuart A ; Newnes, Linda B ; Li, M ; Staniforth, J N ; Tobyn, M J ; Kay, G R ; Horrill, M D ; Lamming, R C ; Hajee, D W ; Wong, D ; Page, T. / A preliminary study of size reduction of powders in a single-vessel pharmaceutical processor. In: Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture. 2000 ; Vol. 214, No. 3. pp. 251-253.
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T1 - A preliminary study of size reduction of powders in a single-vessel pharmaceutical processor

AU - MacGregor, Stuart A

AU - Newnes, Linda B

AU - Li, M

AU - Staniforth, J N

AU - Tobyn, M J

AU - Kay, G R

AU - Horrill, M D

AU - Lamming, R C

AU - Hajee, D W

AU - Wong, D

AU - Page, T

PY - 2000

Y1 - 2000

N2 - The size reduction performance of a pneumatically driven single-vessel pharmaceutical processor is described. Two materials were considered, namely commercially available granular lactose (CAGL) and high-speed mixer granulator lactose (HSMGL). In both cases there is an initial phase in which the particle diameter is reduced rapidly. The rate at which the size reduction decreases is reduced with time. The final particle diameter was found to be dependent on the material being processed. In the case of CAGL, the minimum size achieved was 150 mu m, while in the case of the HSMGL the final particle diameter was 100 mu m

AB - The size reduction performance of a pneumatically driven single-vessel pharmaceutical processor is described. Two materials were considered, namely commercially available granular lactose (CAGL) and high-speed mixer granulator lactose (HSMGL). In both cases there is an initial phase in which the particle diameter is reduced rapidly. The rate at which the size reduction decreases is reduced with time. The final particle diameter was found to be dependent on the material being processed. In the case of CAGL, the minimum size achieved was 150 mu m, while in the case of the HSMGL the final particle diameter was 100 mu m

M3 - Article

VL - 214

SP - 251

EP - 253

JO - Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture

JF - Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture

SN - 0954-4054

IS - 3

ER -