A practical synthesis of enantiopure (S)-4-(4-hydroxybenzyl)-oxazolidin-2-one

R Green, P J M Taylor, S D Bull, T D James, M F Mahon, A T Merritt

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Abstract

A high yielding four-step synthesis of enantiopure 4-(4-hydroxybenzyl)-oxazolidin-2-one (S)-1 from N-Boc-L-tyrosine is described. (S)-1 is a key intermediate for the preparation of a number of polymer supported Evans' oxazolidin-2-ones that have been employed previously for solid supported asymmetric synthesis. (C) 2003 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)2619-2623
Number of pages5
JournalTetrahedron: Asymmetry
Volume14
Issue number17
DOIs
Publication statusPublished - 2003

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Oxazolidinones
tyrosine
synthesis
Tyrosine
Polymers
preparation
polymers

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A practical synthesis of enantiopure (S)-4-(4-hydroxybenzyl)-oxazolidin-2-one. / Green, R; Taylor, P J M; Bull, S D; James, T D; Mahon, M F; Merritt, A T.

In: Tetrahedron: Asymmetry, Vol. 14, No. 17, 2003, p. 2619-2623.

Research output: Contribution to journalArticle

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