A practical synthesis of enantiopure (S)-4-(4-hydroxybenzyl)-oxazolidin-2-one

R Green; P J M Taylor; S D Bull; T D James; M F Mahon; A T Merritt

doi:10.1016/s0957-4166(03)00482-8

A practical synthesis of enantiopure (S)-4-(4-hydroxybenzyl)-oxazolidin-2-one

R Green, P J M Taylor, S D Bull, T D James, M F Mahon, A T Merritt

Department of Chemistry

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24 Citations (SciVal)

Abstract

A high yielding four-step synthesis of enantiopure 4-(4-hydroxybenzyl)-oxazolidin-2-one (S)-1 from N-Boc-L-tyrosine is described. (S)-1 is a key intermediate for the preparation of a number of polymer supported Evans' oxazolidin-2-ones that have been employed previously for solid supported asymmetric synthesis. (C) 2003 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	2619-2623
Number of pages	5
Journal	Tetrahedron: Asymmetry
Volume	14
Issue number	17
DOIs	https://doi.org/10.1016/s0957-4166(03)00482-8
Publication status	Published - 2003

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ID number: ISI:000185311200020

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abstract = "A high yielding four-step synthesis of enantiopure 4-(4-hydroxybenzyl)-oxazolidin-2-one (S)-1 from N-Boc-L-tyrosine is described. (S)-1 is a key intermediate for the preparation of a number of polymer supported Evans' oxazolidin-2-ones that have been employed previously for solid supported asymmetric synthesis. (C) 2003 Elsevier Ltd. All rights reserved.",

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AU - Bull, S D

AU - James, T D

AU - Mahon, M F

AU - Merritt, A T

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AB - A high yielding four-step synthesis of enantiopure 4-(4-hydroxybenzyl)-oxazolidin-2-one (S)-1 from N-Boc-L-tyrosine is described. (S)-1 is a key intermediate for the preparation of a number of polymer supported Evans' oxazolidin-2-ones that have been employed previously for solid supported asymmetric synthesis. (C) 2003 Elsevier Ltd. All rights reserved.

U2 - 10.1016/s0957-4166(03)00482-8

DO - 10.1016/s0957-4166(03)00482-8

M3 - Article

SN - 0957-4166

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JO - Tetrahedron: Asymmetry

JF - Tetrahedron: Asymmetry

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ER -

A practical synthesis of enantiopure (S)-4-(4-hydroxybenzyl)-oxazolidin-2-one

Abstract

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