A practical synthesis of 1,3-disubstituted cubane derivatives

Nahin Kazi; Marine Aublette; Sarah Allinson; Susannah Coote

doi:10.1039/d3cc02164e

A practical synthesis of 1,3-disubstituted cubane derivatives

Nahin Kazi, Marine Aublette, Sarah Allinson, Susannah Coote

Department of Chemistry

Lancaster University

Research output: Contribution to journal › Article › peer-review

13 Citations (SciVal)

Abstract

A robust multigram-scale synthesis of 1,3-disubstituted cubanes (previously only available on milligram-scale) is reported. The approach exploits a readily available enone intermediate previously used for the synthesis of 1,4-disubstituted cubanes, by introducing a novel Wharton transposition to access useful quantities of 1,3-disubstituted cubanes for diverse applications.

Original language	English
Pages (from-to)	7971-7973
Number of pages	3
Journal	Chemical communications (Cambridge, England)
Volume	59
Issue number	51
DOIs	https://doi.org/10.1039/d3cc02164e
Publication status	Published - 31 May 2023

Bibliographical note

Funding Information:
This work was supported by funding from North West Cancer Research (LFSL2018-23, Studentship to MCA).

Publisher Copyright:
© 2023 The Royal Society of Chemistry.

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10.1039/d3cc02164eLicence: CC BY

https://pubs.rsc.org/en/content/articlelanding/2023/cc/d3cc02164eLicence: CC BY

Cite this

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abstract = "A robust multigram-scale synthesis of 1,3-disubstituted cubanes (previously only available on milligram-scale) is reported. The approach exploits a readily available enone intermediate previously used for the synthesis of 1,4-disubstituted cubanes, by introducing a novel Wharton transposition to access useful quantities of 1,3-disubstituted cubanes for diverse applications.",

author = "Nahin Kazi and Marine Aublette and Sarah Allinson and Susannah Coote",

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AU - Kazi, Nahin

AU - Aublette, Marine

AU - Allinson, Sarah

AU - Coote, Susannah

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Y1 - 2023/5/31

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AB - A robust multigram-scale synthesis of 1,3-disubstituted cubanes (previously only available on milligram-scale) is reported. The approach exploits a readily available enone intermediate previously used for the synthesis of 1,4-disubstituted cubanes, by introducing a novel Wharton transposition to access useful quantities of 1,3-disubstituted cubanes for diverse applications.

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A practical synthesis of 1,3-disubstituted cubane derivatives

Abstract

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