A practical synthesis of 1,3-disubstituted cubane derivatives

Nahin Kazi, Marine Aublette, Sarah Allinson, Susannah Coote

Research output: Contribution to journalArticlepeer-review

6 Citations (SciVal)


A robust multigram-scale synthesis of 1,3-disubstituted cubanes (previously only available on milligram-scale) is reported. The approach exploits a readily available enone intermediate previously used for the synthesis of 1,4-disubstituted cubanes, by introducing a novel Wharton transposition to access useful quantities of 1,3-disubstituted cubanes for diverse applications.
Original languageEnglish
Pages (from-to)7971-7973
Number of pages3
JournalChemical communications (Cambridge, England)
Issue number51
Publication statusPublished - 31 May 2023

Bibliographical note

Funding Information:
This work was supported by funding from North West Cancer Research (LFSL2018-23, Studentship to MCA).

Publisher Copyright:
© 2023 The Royal Society of Chemistry.


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