A practical protocol for the highly E-selective formation of aryl-substituted silylketene acetals

Wesley R R Harker, E L Carswell, David R Carbery

Research output: Contribution to journalArticle

16 Citations (Scopus)


The E/Z-selectivity in the formation of silylketene acetals derived from phenylacetate esters, mediated by LiHMDS, has been studied by in situ NMR techniques. The formation is seen to be highly E-selective with use of the newly developed protocol. Isolated aryl-substituted silylketene acetals are now attainable with high levels of E-geometrical purity in excellent yield.
Original languageEnglish
Pages (from-to)3712-3715
Number of pages4
JournalOrganic Letters
Issue number16
Publication statusPublished - 20 Aug 2010


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