A powerful mitochondria-targeted iron chelator affords high photoprotection against solar ultraviolet A radiation

Olivier Reelfs, Vincenzo Abbate, Robert C Hider, Charareh Pourzand

Research output: Contribution to journalArticle

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Abstract

Mitochondria are the principal destination for labile iron, making these organelles particularly susceptible to oxidative damage on exposure to ultraviolet A (UVA, 320–400 nm), the oxidizing component of sunlight. The labile iron-mediated oxidative damage caused by UVA to mitochondria leads to necrotic cell death via adenosine triphosphate depletion. Therefore, targeted removal of mitochondrial labile iron via highly specific tools from these organelles may be an effective approach to protect the skin cells against the harmful effects of UVA. In this work, we designed a mitochondria-targeted hexadentate (tricatechol-based) iron chelator linked to mitochondria-homing SS-like peptides. The photoprotective potential of this compound against UVA-induced oxidative damage and cell death was evaluated in cultured primary skin fibroblasts. Our results show that this compound provides unprecedented protection against UVA-induced mitochondrial damage, adenosine triphosphate depletion, and the ensuing necrotic cell death in skin fibroblasts, and this effect is fully related to its potent iron-chelating property in the organelle. This mitochondria-targeted iron chelator has therefore promising potential for skin photoprotection against the deleterious effects of the UVA component of sunlight.
Original languageEnglish
Pages (from-to)1692-1700
Number of pages9
JournalJournal Of Investigative Dermatology
Volume136
Issue number8
Early online date22 Apr 2016
DOIs
Publication statusPublished - 1 Aug 2016

Cite this

A powerful mitochondria-targeted iron chelator affords high photoprotection against solar ultraviolet A radiation. / Reelfs, Olivier; Abbate, Vincenzo; Hider, Robert C; Pourzand, Charareh.

In: Journal Of Investigative Dermatology, Vol. 136, No. 8, 01.08.2016, p. 1692-1700.

Research output: Contribution to journalArticle

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