A polymorphism in the CTGF promoter region associated with systemic sclerosis

Carmen Fonseca, Gisela E Lindahl, Markella Ponticos, Piersante Sestini, Elisabetta A Renzoni, Alan M Holmes, Paolo Spagnolo, Panagiotis Pantelidis, Patricia Leoni, Neil J McHugh, Carmel J Stock, Xu Shi-Wen, Christopher P Denton, Carol M Black, Kenneth I Welsh, Roland M du Bois, David J Abraham

Research output: Contribution to journalArticlepeer-review

154 Citations (Scopus)

Abstract

The G-945C substitution represses CTGF transcription, and the -945G allele is significantly associated with susceptibility to systemic sclerosis.
Original languageEnglish
Pages (from-to)1210-1220
Number of pages11
JournalThe New England Journal of Medicine
Volume357
Issue number12
DOIs
Publication statusPublished - 2007

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