A polymorphism in the CTGF promoter region associated with systemic sclerosis

Carmen Fonseca, Gisela E Lindahl, Markella Ponticos, Piersante Sestini, Elisabetta A Renzoni, Alan M Holmes, Paolo Spagnolo, Panagiotis Pantelidis, Patricia Leoni, Neil J McHugh, Carmel J Stock, Xu Shi-Wen, Christopher P Denton, Carol M Black, Kenneth I Welsh, Roland M du Bois, David J Abraham

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149 Citations (Scopus)

Abstract

The G-945C substitution represses CTGF transcription, and the -945G allele is significantly associated with susceptibility to systemic sclerosis.
Original languageEnglish
Pages (from-to)1210-1220
Number of pages11
JournalThe New England Journal of Medicine
Volume357
Issue number12
DOIs
Publication statusPublished - 2007

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  • Cite this

    Fonseca, C., Lindahl, G. E., Ponticos, M., Sestini, P., Renzoni, E. A., Holmes, A. M., Spagnolo, P., Pantelidis, P., Leoni, P., McHugh, N. J., Stock, C. J., Shi-Wen, X., Denton, C. P., Black, C. M., Welsh, K. I., du Bois, R. M., & Abraham, D. J. (2007). A polymorphism in the CTGF promoter region associated with systemic sclerosis. The New England Journal of Medicine, 357(12), 1210-1220. https://doi.org/10.1056/NEJMoa067655