A polymorphism in the CTGF promoter region associated with systemic sclerosis

Carmen Fonseca; Gisela E Lindahl; Markella Ponticos; Piersante Sestini; Elisabetta A Renzoni; Alan M Holmes; Paolo Spagnolo; Panagiotis Pantelidis; Patricia Leoni; Neil J McHugh; Carmel J Stock; Xu Shi-Wen; Christopher P Denton; Carol M Black; Kenneth I Welsh; Roland M du Bois; David J Abraham

doi:10.1056/NEJMoa067655

A polymorphism in the CTGF promoter region associated with systemic sclerosis

Carmen Fonseca, Gisela E Lindahl, Markella Ponticos, Piersante Sestini, Elisabetta A Renzoni, Alan M Holmes, Paolo Spagnolo, Panagiotis Pantelidis, Patricia Leoni, Neil J McHugh, Carmel J Stock, Xu Shi-Wen, Christopher P Denton, Carol M Black, Kenneth I Welsh, Roland M du Bois, David J Abraham

Research output: Contribution to journal › Article › peer-review

183 Citations (SciVal)

Abstract

The G-945C substitution represses CTGF transcription, and the -945G allele is significantly associated with susceptibility to systemic sclerosis.

Original language	English
Pages (from-to)	1210-1220
Number of pages	11
Journal	The New England Journal of Medicine
Volume	357
Issue number	12
DOIs	https://doi.org/10.1056/NEJMoa067655
Publication status	Published - 2007

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Fonseca, C., Lindahl, G. E., Ponticos, M., Sestini, P., Renzoni, E. A., Holmes, A. M., Spagnolo, P., Pantelidis, P., Leoni, P., McHugh, N. J., Stock, C. J., Shi-Wen, X., Denton, C. P., Black, C. M., Welsh, K. I., du Bois, R. M., & Abraham, D. J. (2007). A polymorphism in the CTGF promoter region associated with systemic sclerosis. The New England Journal of Medicine, 357(12), 1210-1220. https://doi.org/10.1056/NEJMoa067655

Fonseca, C, Lindahl, GE, Ponticos, M, Sestini, P, Renzoni, EA, Holmes, AM, Spagnolo, P, Pantelidis, P, Leoni, P, McHugh, NJ, Stock, CJ, Shi-Wen, X, Denton, CP, Black, CM, Welsh, KI, du Bois, RM & Abraham, DJ 2007, 'A polymorphism in the CTGF promoter region associated with systemic sclerosis', The New England Journal of Medicine, vol. 357, no. 12, pp. 1210-1220. https://doi.org/10.1056/NEJMoa067655

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title = "A polymorphism in the CTGF promoter region associated with systemic sclerosis",

abstract = "The G-945C substitution represses CTGF transcription, and the -945G allele is significantly associated with susceptibility to systemic sclerosis.",

author = "Carmen Fonseca and Lindahl, {Gisela E} and Markella Ponticos and Piersante Sestini and Renzoni, {Elisabetta A} and Holmes, {Alan M} and Paolo Spagnolo and Panagiotis Pantelidis and Patricia Leoni and McHugh, {Neil J} and Stock, {Carmel J} and Xu Shi-Wen and Denton, {Christopher P} and Black, {Carol M} and Welsh, {Kenneth I} and {du Bois}, {Roland M} and Abraham, {David J}",

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doi = "10.1056/NEJMoa067655",

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volume = "357",

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T1 - A polymorphism in the CTGF promoter region associated with systemic sclerosis

AU - Fonseca, Carmen

AU - Lindahl, Gisela E

AU - Ponticos, Markella

AU - Sestini, Piersante

AU - Renzoni, Elisabetta A

AU - Holmes, Alan M

AU - Spagnolo, Paolo

AU - Pantelidis, Panagiotis

AU - Leoni, Patricia

AU - McHugh, Neil J

AU - Stock, Carmel J

AU - Shi-Wen, Xu

AU - Denton, Christopher P

AU - Black, Carol M

AU - Welsh, Kenneth I

AU - du Bois, Roland M

AU - Abraham, David J

PY - 2007

Y1 - 2007

N2 - The G-945C substitution represses CTGF transcription, and the -945G allele is significantly associated with susceptibility to systemic sclerosis.

AB - The G-945C substitution represses CTGF transcription, and the -945G allele is significantly associated with susceptibility to systemic sclerosis.

UR - http://dx.doi.org/10.1056/NEJMoa067655

U2 - 10.1056/NEJMoa067655

DO - 10.1056/NEJMoa067655

M3 - Article

SN - 0028-4793

VL - 357

SP - 1210

EP - 1220

JO - The New England Journal of Medicine

JF - The New England Journal of Medicine

IS - 12

ER -

A polymorphism in the CTGF promoter region associated with systemic sclerosis

Abstract

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