A photosensitive sustainable lignin nanoplatform for multimodal image-guided mitochondria-targeted photodynamic and photothermal therapy

X. Liu, M. Li, X. Li, M. Ge, S. Liu, S. Li, J. Li, J. Ding, A. J. Ragauskas, W. Sun, T. D. James, Z. Chen

Research output: Contribution to journalArticlepeer-review

6 Citations (SciVal)

Abstract

Photoactivated nanocarriers exhibit significant potential for anticancer therapy, but complex design strategies, unsustainable substrates, and short wavelengths limit their practical application. Here, we designed a new lignin-derived photoactivated nanomaterial that exploits the sensitivity of the β-O-4 bond of lignin to singlet oxygen. This sustainable product was loaded with mitochondria-targeting chlorin e6 and black phosphorus quantum dots (BPQDs) to produce BPQDs@N-LgC NPs, which were used for mitochondria-targeted fluorescence/photoacoustic-guided photothermal and photodynamic therapy. When irradiated at 808 nm, the BPQDs in BPQDs@N-LgC NPs exhibited good photothermal conversion, which allowed photoacoustic imaging and inhibited tumor growth. When irradiated at 660 nm, the BPQDs@N-LgC NPs generated fluorescence and reactive oxygen species, which allowed photoluminescence imaging and further inhibited tumor growth. Cleavage of the β-O-4 bond of lignin by photo-triggered reactive oxygen species degraded the NPs and released the BPQDs, facilitating rapid excretion of the therapeutic nanomaterials. Our rationally designed BPQDs@N-LgC NPs exhibited good therapeutic efficacy, both in vitro and in vivo.

Original languageEnglish
Article number101000
JournalMaterials Today Chemistry
Volume26
Early online date4 Jul 2022
DOIs
Publication statusPublished - 31 Dec 2022

Bibliographical note

Funding Information:
This work was supported by the National Natural Science Foundation of China ( 31890774 and 31800494 ), Natural Science Funding of Heilong Jiang province for Excellent Young Scholar (YQ2020C017). TDJ wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01).

Keywords

  • Multimodal imaging
  • Photodynamic and photothermal synergistic therapy
  • Photosensitive lignin nanoplatform
  • reactive oxygen species

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Polymers and Plastics
  • Colloid and Surface Chemistry
  • Materials Chemistry

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