A one-pot synthesis of α-formyl-α-allylacetates via nucleophilic catalysis.

William Chung, Petra Lindovska, Jason E. Camp

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

A step-economical one-pot nucleophilic catalysis/thermal Claisen rearrangement protocol for the direct synthesis of α-formyl-α-allylacetates from allylic alcs. and activated alkynes has been developed. The product α-formyl-α-allylacetates were further reacted in situ to give either protected enol ethers or β-hydroxy-4-pentenoates. [on SciFinder(R)]
Original languageEnglish
Pages (from-to)6785-6787
Number of pages3
JournalTetrahedron Letters
Volume52
Issue number50
DOIs
Publication statusPublished - 14 Dec 2011

Keywords

  • allylic alc activated alkyne nucleophilic catalysis addn Claisen rearrangement
  • formyl allylacetate prepn protection redn

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