A one-pot, reductive amination/6-endo-trig cyclisation for the stereoselective synthesis of 6-substituted-4-oxopipecolic acids

Lynne Thomas

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

The first stereoselective synthesis of 2,6-trans-6-substituted-4-oxo-L-pipecolic acids using a tandem reductive amination/6-endo-trigcyclisation process is described. The sequential reduction and cyclisation mediated by sodium cyanoborohydride allowed the preparation of a series of highly functionalised 6-alkyl and 6-aryl analogues.
Original languageEnglish
Pages (from-to)6569-6571
Number of pages3
JournalChemical Communications
Volume47
DOIs
Publication statusPublished - 2011

Fingerprint

Dive into the research topics of 'A one-pot, reductive amination/6-endo-trig cyclisation for the stereoselective synthesis of 6-substituted-4-oxopipecolic acids'. Together they form a unique fingerprint.

Cite this