A novel apparatus for the determination of solubility in pressurized metered dose inhalers

D Traini, P M Young, R Price, P Rogueda

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The accurate solubility of salbutamol sulfate, budesonide, and formoterol fumarate dihydrate in hydrofluoroalkane propellant 134a at 25 degrees C for 24 h, are reported. The authors describe a novel reusable in-line pressurized solubility apparatus containing an integral filter holder and a continuous decrimpable valve for the determination of drug/excipients solubility in pressurized metered dose inhalers. The solubility was determined by high-performance liquid chromatography. Solubility of salbutamol sulfate was determined as being below the detection limits while budesonide and formoterol fumarate dihydrate solubility were 23.136 +/- 2.951 mu g. g(-1) and 0.776 +/- 1.023 mu g. g(-1), respectively (n = 3). This novel solubility apparatus offers an improved ease of use and potential higher analytical throughput.
Original languageEnglish
Pages (from-to)1159-1163
Number of pages5
JournalDrug Development and Industrial Pharmacy
Volume32 Nov-Dec
Issue number10
DOIs
Publication statusPublished - 2006

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