A new synthesis and preliminary evaluation of some analogues of mecamylamine-a compound with anti-addiction properties

David Mangan; Neasa McNabola; Emily H. Clark; Isabel Bermudez; Susan Wonnacott; J. Mike Southern

doi:10.1039/C6OB01974A

A new synthesis and preliminary evaluation of some analogues of mecamylamine-a compound with anti-addiction properties

David Mangan, Neasa McNabola, Emily H. Clark, Isabel Bermudez, Susan Wonnacott, J. Mike Southern

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

3 Citations (SciVal)

Abstract

A new synthesis of mecamylamine-a known anti-hypertensive drug with anti-addictive properties is described. The new route allowed access to two novel analogues whose activity at two nicotinic acetylcholine receptor subtypes was assessed.

Original language	English
Pages (from-to)	10787-10798
Number of pages	12
Journal	Organic and Biomolecular Chemistry
Volume	14
Issue number	46
DOIs	https://doi.org/10.1039/C6OB01974A
Publication status	Published - 14 Dec 2016

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10.1039/C6OB01974A

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title = "A new synthesis and preliminary evaluation of some analogues of mecamylamine-a compound with anti-addiction properties",

abstract = "A new synthesis of mecamylamine-a known anti-hypertensive drug with anti-addictive properties is described. The new route allowed access to two novel analogues whose activity at two nicotinic acetylcholine receptor subtypes was assessed.",

author = "David Mangan and Neasa McNabola and Clark, {Emily H.} and Isabel Bermudez and Susan Wonnacott and Southern, {J. Mike}",

year = "2016",

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doi = "10.1039/C6OB01974A",

language = "English",

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journal = "Organic and Biomolecular Chemistry",

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publisher = "Royal Society of Chemistry",

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T1 - A new synthesis and preliminary evaluation of some analogues of mecamylamine-a compound with anti-addiction properties

AU - Mangan, David

AU - McNabola, Neasa

AU - Clark, Emily H.

AU - Bermudez, Isabel

AU - Wonnacott, Susan

AU - Southern, J. Mike

PY - 2016/12/14

Y1 - 2016/12/14

N2 - A new synthesis of mecamylamine-a known anti-hypertensive drug with anti-addictive properties is described. The new route allowed access to two novel analogues whose activity at two nicotinic acetylcholine receptor subtypes was assessed.

AB - A new synthesis of mecamylamine-a known anti-hypertensive drug with anti-addictive properties is described. The new route allowed access to two novel analogues whose activity at two nicotinic acetylcholine receptor subtypes was assessed.

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UR - http://dx.doi.org/10.1039/C6OB01974A

U2 - 10.1039/C6OB01974A

DO - 10.1039/C6OB01974A

M3 - Article

AN - SCOPUS:84998590334

SN - 1477-0520

VL - 14

SP - 10787

EP - 10798

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 46

ER -

A new synthesis and preliminary evaluation of some analogues of mecamylamine-a compound with anti-addiction properties

Abstract

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Avance III 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (9West)

Avance NEO 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (1South)

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A new synthesis and preliminary evaluation of some analogues of mecamylamine-a compound with anti-addiction properties

Abstract

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Avance III 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (9West)

Avance NEO 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (1South)

Cite this