A new online monitoring method for water-in-oil droplet based microfluidic devices

Y He; Y Jiang; T Zhang; H Ji; B Wang; Z Huang; Manuchehr Soleimani

doi:10.1109/JSEN.2022.3181998

A new online monitoring method for water-in-oil droplet based microfluidic devices

Y He, Y Jiang, T Zhang, H Ji, B Wang, Z Huang, Manuchehr Soleimani

Zhejiang University

Research output: Contribution to journal › Article › peer-review

2 Citations (SciVal)

148 Downloads (Pure)

Abstract

The online water-in-oil (w/o) droplet monitoring is essential for the uniformity of the droplet based microfluidic devices. In this work, a contactless impedance detection (CID) method for online w/o droplet monitoring in microfluidic devices is proposed. In the proposed method, a new CID sensor, which can work at low working frequency and overcome the unfavorable influence of coupling capacitance, is developed to obtain the impedance information of the w/o droplet. Based on the obtained impedance information, measurement models are established to realize online measurement of drop length and dispersed phase holdup. Then the coefficients of variation (CVs) of the two measured parameters are calculated to evaluate the uniformity of the droplets for online monitoring. Online monitoring experiments of w/o droplet were carried out in a microfluidic device with a 500 μ m× 500 μ m microchannel. The experimental results verify the effectiveness of the proposed droplet monitoring method. The developed CID sensor can realize impedance measurement at a working frequency lower than 50kHz. The drop length and dispersed phase holdup are useful parameters for online monitoring of droplets. With the established measurement models, the maximum relative error of droplet length measurement is less than 10% in the droplet length range of 1.5mm-3.5mm. And the maximum error of dispersed phase holdup measurement is less than 5% in the dispersed phase holdup range of 0.20-0.67.

Original language	English
Pages (from-to)	4373 - 4382
Number of pages	10
Journal	IEEE Sensors Journal
Volume	23
Issue number	5
Early online date	16 Jun 2022
DOIs	https://doi.org/10.1109/JSEN.2022.3181998
Publication status	Published - 1 Mar 2023

Bibliographical note

This work was supported in part by the National Natural Science
Foundation of China under Grant 61573312. (Corresponding author:
Yandan Jiang).

Funding Information:
This study was supported by grant NSC 94-2312-B-040-002 from the National Science Council, Taiwan.

Keywords

Capacitance
Couplings
Electrodes
Impedance
Microfluidics
Monitoring
Sensors
contactless impedance detection
dispersed phase holdup
droplet length
droplet monitoring
microfluidic

ASJC Scopus subject areas

Instrumentation
Electrical and Electronic Engineering

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10.1109/JSEN.2022.3181998

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Cite this

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title = "A new online monitoring method for water-in-oil droplet based microfluidic devices",

abstract = "The online water-in-oil (w/o) droplet monitoring is essential for the uniformity of the droplet based microfluidic devices. In this work, a contactless impedance detection (CID) method for online w/o droplet monitoring in microfluidic devices is proposed. In the proposed method, a new CID sensor, which can work at low working frequency and overcome the unfavorable influence of coupling capacitance, is developed to obtain the impedance information of the w/o droplet. Based on the obtained impedance information, measurement models are established to realize online measurement of drop length and dispersed phase holdup. Then the coefficients of variation (CVs) of the two measured parameters are calculated to evaluate the uniformity of the droplets for online monitoring. Online monitoring experiments of w/o droplet were carried out in a microfluidic device with a 500 μ m× 500 μ m microchannel. The experimental results verify the effectiveness of the proposed droplet monitoring method. The developed CID sensor can realize impedance measurement at a working frequency lower than 50kHz. The drop length and dispersed phase holdup are useful parameters for online monitoring of droplets. With the established measurement models, the maximum relative error of droplet length measurement is less than 10% in the droplet length range of 1.5mm-3.5mm. And the maximum error of dispersed phase holdup measurement is less than 5% in the dispersed phase holdup range of 0.20-0.67.",

keywords = "Capacitance, Couplings, Electrodes, Impedance, Microfluidics, Monitoring, Sensors, contactless impedance detection, dispersed phase holdup, droplet length, droplet monitoring, microfluidic",

author = "Y He and Y Jiang and T Zhang and H Ji and B Wang and Z Huang and Manuchehr Soleimani",

note = "This work was supported in part by the National Natural Science Foundation of China under Grant 61573312. (Corresponding author: Yandan Jiang). Funding Information: This study was supported by grant NSC 94-2312-B-040-002 from the National Science Council, Taiwan. ",

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doi = "10.1109/JSEN.2022.3181998",

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AU - Zhang, T

AU - Ji, H

AU - Wang, B

AU - Huang, Z

AU - Soleimani, Manuchehr

N1 - This work was supported in part by the National Natural Science Foundation of China under Grant 61573312. (Corresponding author: Yandan Jiang). Funding Information: This study was supported by grant NSC 94-2312-B-040-002 from the National Science Council, Taiwan.

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N2 - The online water-in-oil (w/o) droplet monitoring is essential for the uniformity of the droplet based microfluidic devices. In this work, a contactless impedance detection (CID) method for online w/o droplet monitoring in microfluidic devices is proposed. In the proposed method, a new CID sensor, which can work at low working frequency and overcome the unfavorable influence of coupling capacitance, is developed to obtain the impedance information of the w/o droplet. Based on the obtained impedance information, measurement models are established to realize online measurement of drop length and dispersed phase holdup. Then the coefficients of variation (CVs) of the two measured parameters are calculated to evaluate the uniformity of the droplets for online monitoring. Online monitoring experiments of w/o droplet were carried out in a microfluidic device with a 500 μ m× 500 μ m microchannel. The experimental results verify the effectiveness of the proposed droplet monitoring method. The developed CID sensor can realize impedance measurement at a working frequency lower than 50kHz. The drop length and dispersed phase holdup are useful parameters for online monitoring of droplets. With the established measurement models, the maximum relative error of droplet length measurement is less than 10% in the droplet length range of 1.5mm-3.5mm. And the maximum error of dispersed phase holdup measurement is less than 5% in the dispersed phase holdup range of 0.20-0.67.

AB - The online water-in-oil (w/o) droplet monitoring is essential for the uniformity of the droplet based microfluidic devices. In this work, a contactless impedance detection (CID) method for online w/o droplet monitoring in microfluidic devices is proposed. In the proposed method, a new CID sensor, which can work at low working frequency and overcome the unfavorable influence of coupling capacitance, is developed to obtain the impedance information of the w/o droplet. Based on the obtained impedance information, measurement models are established to realize online measurement of drop length and dispersed phase holdup. Then the coefficients of variation (CVs) of the two measured parameters are calculated to evaluate the uniformity of the droplets for online monitoring. Online monitoring experiments of w/o droplet were carried out in a microfluidic device with a 500 μ m× 500 μ m microchannel. The experimental results verify the effectiveness of the proposed droplet monitoring method. The developed CID sensor can realize impedance measurement at a working frequency lower than 50kHz. The drop length and dispersed phase holdup are useful parameters for online monitoring of droplets. With the established measurement models, the maximum relative error of droplet length measurement is less than 10% in the droplet length range of 1.5mm-3.5mm. And the maximum error of dispersed phase holdup measurement is less than 5% in the dispersed phase holdup range of 0.20-0.67.

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JF - IEEE Sensors Journal

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ER -

A new online monitoring method for water-in-oil droplet based microfluidic devices

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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