A new method for constructing quaternary carbon centres: Tandem rhodium-catalysed 1,4-addition/intramolecular cyclisation

J. Le Nôtre; D. Van Mele; C.G. Frost

doi:10.1002/adsc.200600355

A new method for constructing quaternary carbon centres: Tandem rhodium-catalysed 1,4-addition/intramolecular cyclisation

J. Le Nôtre
, D. Van Mele
, C.G. Frost

Research output: Contribution to journal › Article › peer-review

20 Citations (SciVal)

Abstract

The efficient tandem rhodium-catalysed 1,4-addition/cyclisation of 1,1′-alkenes using arylzinc chlorides is described. The simple one-step synthesis of substituted cyclopentanone and cyclohexanone derivatives is performed from acyclic precursors using relatively low catalyst loadings under mild conditions. A new quaternary carbon centre is created during the cyclisation step.

Original language	English
Pages (from-to)	432-440
Number of pages	9
Journal	Advanced Synthesis & Catalysis
Volume	349
Issue number	3
DOIs	https://doi.org/10.1002/adsc.200600355
Publication status	Published - 1 Feb 2007

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10.1002/adsc.200600355

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abstract = "The efficient tandem rhodium-catalysed 1,4-addition/cyclisation of 1,1′-alkenes using arylzinc chlorides is described. The simple one-step synthesis of substituted cyclopentanone and cyclohexanone derivatives is performed from acyclic precursors using relatively low catalyst loadings under mild conditions. A new quaternary carbon centre is created during the cyclisation step.",

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AB - The efficient tandem rhodium-catalysed 1,4-addition/cyclisation of 1,1′-alkenes using arylzinc chlorides is described. The simple one-step synthesis of substituted cyclopentanone and cyclohexanone derivatives is performed from acyclic precursors using relatively low catalyst loadings under mild conditions. A new quaternary carbon centre is created during the cyclisation step.

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A new method for constructing quaternary carbon centres: Tandem rhodium-catalysed 1,4-addition/intramolecular cyclisation

Abstract

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