A new method for constructing quaternary carbon centres: Tandem rhodium-catalysed 1,4-addition/intramolecular cyclisation

J. Le Nôtre, D. Van Mele, C.G. Frost

Research output: Contribution to journalArticle

14 Citations (Scopus)


The efficient tandem rhodium-catalysed 1,4-addition/cyclisation of 1,1′-alkenes using arylzinc chlorides is described. The simple one-step synthesis of substituted cyclopentanone and cyclohexanone derivatives is performed from acyclic precursors using relatively low catalyst loadings under mild conditions. A new quaternary carbon centre is created during the cyclisation step.
Original languageEnglish
Pages (from-to)432-440
Number of pages9
JournalAdvanced Synthesis & Catalysis
Issue number3
Publication statusPublished - 1 Feb 2007


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