TY - JOUR
T1 - A new method for constructing quaternary carbon centres
T2 - Tandem rhodium-catalysed 1,4-addition/intramolecular cyclisation
AU - Le Nôtre, J.
AU - Van Mele, D.
AU - Frost, C.G.
PY - 2007/2/1
Y1 - 2007/2/1
N2 - The efficient tandem rhodium-catalysed 1,4-addition/cyclisation of 1,1′-alkenes using arylzinc chlorides is described. The simple one-step synthesis of substituted cyclopentanone and cyclohexanone derivatives is performed from acyclic precursors using relatively low catalyst loadings under mild conditions. A new quaternary carbon centre is created during the cyclisation step.
AB - The efficient tandem rhodium-catalysed 1,4-addition/cyclisation of 1,1′-alkenes using arylzinc chlorides is described. The simple one-step synthesis of substituted cyclopentanone and cyclohexanone derivatives is performed from acyclic precursors using relatively low catalyst loadings under mild conditions. A new quaternary carbon centre is created during the cyclisation step.
UR - http://www.scopus.com/inward/record.url?scp=34547183283&partnerID=8YFLogxK
UR - http://dx.doi.org/10.1002/adsc.200600355
U2 - 10.1002/adsc.200600355
DO - 10.1002/adsc.200600355
M3 - Article
AN - SCOPUS:34547183283
SN - 1615-4150
VL - 349
SP - 432
EP - 440
JO - Advanced Synthesis & Catalysis
JF - Advanced Synthesis & Catalysis
IS - 3
ER -