A new method for constructing quaternary carbon centres

Tandem rhodium-catalysed 1,4-addition/intramolecular cyclisation

J. Le Nôtre, D. Van Mele, C.G. Frost

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The efficient tandem rhodium-catalysed 1,4-addition/cyclisation of 1,1′-alkenes using arylzinc chlorides is described. The simple one-step synthesis of substituted cyclopentanone and cyclohexanone derivatives is performed from acyclic precursors using relatively low catalyst loadings under mild conditions. A new quaternary carbon centre is created during the cyclisation step.
Original languageEnglish
Pages (from-to)432-440
Number of pages9
JournalAdvanced Synthesis & Catalysis
Volume349
Issue number3
DOIs
Publication statusPublished - 1 Feb 2007

Fingerprint

Rhodium
Cyclization
Carbon
Alkenes
Olefins
Chlorides
Derivatives
Catalysts
cyclopentanone
cyclohexanone

Cite this

A new method for constructing quaternary carbon centres : Tandem rhodium-catalysed 1,4-addition/intramolecular cyclisation. / Le Nôtre, J.; Van Mele, D.; Frost, C.G.

In: Advanced Synthesis & Catalysis, Vol. 349, No. 3, 01.02.2007, p. 432-440.

Research output: Contribution to journalArticle

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