A novel near-infrared (NIR) and colorimetric fluorescent molecular probe based on a dicyanomethylene-4H-pyran chromophore for the selective detection of glutathione in living cells has been developed. The fluorescence OFF–ON switch is triggered by cleavage of the 2,4-dinitrobenzensulfonyl (DNBS) unit by the interaction with GSH.
Li, M., Wu, X., Wang, Y., Li, Y., Zhu, W., & James, T. D. (2014). A near-infrared colorimetric fluorescent chemodosimeter for the detection of glutathione in living cells. Chemical Communications, 50(14), 1751-1753. https://doi.org/10.1039/c3cc48128j