A multicentre study of validity and reliability of responses to hand cold challenge as measured by laser speckle contrast imaging and thermography: outcome measures for systemic sclerosis-related Raynaud's phenomenon

Jack D Wilkinson, Sarah A Leggett, Elizabeth J Marjanovic, Tonia L Moore, John Allen, Marina E Anderson, Jason Britton, Maya H Buch, Francesco Del Galdo, Christopher P Denton, Graham Dinsdale, Bridgett Griffiths, Frances Hall, Kevin Howell, Audrey MacDonald, Neil J McHugh, Joanne B Manning, John D Pauling, Christopher Roberts, Jacqueline A Shipley & 2 others Ariane L Herrick, Andrea K Murray

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Abstract

BACKGROUND: Objective and reliable outcome measures to facilitate clinical trials of novel treatments for systemic sclerosis (SSc)-related Raynaud's phenomenon (RP) are badly needed. Laser speckle contrast imaging (LSCI) and thermography are non-invasive measures of perfusion that show excellent potential. The purpose of this multi-centre study was to determine the reliability and validity of a hand cold challenge protocol using LSCI, standard thermography and low-cost mobile phone-based thermography.

METHODS: Patients with RP secondary to SSc were recruited from 6 UK tertiary-SSc centres and underwent cold challenge on 2 consecutive days. Changes in cutaneous perfusion/temperature at each visit were imaged simultaneously using LSCI, standard and mobile phone thermography. Measurements included area under reperfusion/rewarming curve (AUC) and maximum perfusion/rewarming (MAX). Test-retest reliability was assessed using intraclass correlation coefficients (ICC). Estimated latent correlations assessed convergent validity of LSCI and thermography.

RESULTS: 159 patients were recruited (84% female, 77% limited cutaneous, median age 63.3 years). LSCI and standard thermography both had substantial reliability, ICCs (95%CI) for AUC were 0.67(0.54-0.76) and 0.68(0.58-0.80) respectively, and for MAX were 0.64(0.52-0.75) and 0.72(0.64-0.81) respectively. Very high latent correlations (95% CI) were present for AUCs of LSCI and thermography [0.94(0.87-1.00)], and for AUCs of standard and mobile phone thermography [0.98(0.94-1.00)].

CONCLUSION: This is the first multi-centre study examining reliability and validity of cold challenge using LSCI and thermography in patients with SSc-related RP. LSCI and thermography demonstrated good potential as outcome measures. LSCI, standard and mobile phone thermography had very high convergent validity. This article is protected by copyright. All rights reserved.

LanguageEnglish
Pages903-911
JournalArthritis & Rheumatology
Volume70
Issue number6
Early online date18 Feb 2018
DOIs
StatusPublished - 1 Jun 2018

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Raynaud Disease
Systemic Scleroderma
Reproducibility of Results
Multicenter Studies
Lasers
Hand
Outcome Assessment (Health Care)
Cell Phones
Area Under Curve
Rewarming
Perfusion
Skin Temperature
Reperfusion
Clinical Trials

Keywords

  • Journal Article

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A multicentre study of validity and reliability of responses to hand cold challenge as measured by laser speckle contrast imaging and thermography : outcome measures for systemic sclerosis-related Raynaud's phenomenon. / Wilkinson, Jack D; Leggett, Sarah A; Marjanovic, Elizabeth J; Moore, Tonia L; Allen, John; Anderson, Marina E; Britton, Jason; Buch, Maya H; Galdo, Francesco Del; Denton, Christopher P; Dinsdale, Graham; Griffiths, Bridgett; Hall, Frances; Howell, Kevin; MacDonald, Audrey; McHugh, Neil J; Manning, Joanne B; Pauling, John D; Roberts, Christopher; Shipley, Jacqueline A; Herrick, Ariane L; Murray, Andrea K.

In: Arthritis & Rheumatology, Vol. 70, No. 6, 01.06.2018, p. 903-911.

Research output: Contribution to journalArticle

Wilkinson, JD, Leggett, SA, Marjanovic, EJ, Moore, TL, Allen, J, Anderson, ME, Britton, J, Buch, MH, Galdo, FD, Denton, CP, Dinsdale, G, Griffiths, B, Hall, F, Howell, K, MacDonald, A, McHugh, NJ, Manning, JB, Pauling, JD, Roberts, C, Shipley, JA, Herrick, AL & Murray, AK 2018, 'A multicentre study of validity and reliability of responses to hand cold challenge as measured by laser speckle contrast imaging and thermography: outcome measures for systemic sclerosis-related Raynaud's phenomenon' Arthritis & Rheumatology, vol. 70, no. 6, pp. 903-911. DOI: 10.1002/art.40457
Wilkinson, Jack D ; Leggett, Sarah A ; Marjanovic, Elizabeth J ; Moore, Tonia L ; Allen, John ; Anderson, Marina E ; Britton, Jason ; Buch, Maya H ; Galdo, Francesco Del ; Denton, Christopher P ; Dinsdale, Graham ; Griffiths, Bridgett ; Hall, Frances ; Howell, Kevin ; MacDonald, Audrey ; McHugh, Neil J ; Manning, Joanne B ; Pauling, John D ; Roberts, Christopher ; Shipley, Jacqueline A ; Herrick, Ariane L ; Murray, Andrea K. / A multicentre study of validity and reliability of responses to hand cold challenge as measured by laser speckle contrast imaging and thermography : outcome measures for systemic sclerosis-related Raynaud's phenomenon. In: Arthritis & Rheumatology. 2018 ; Vol. 70, No. 6. pp. 903-911
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abstract = "BACKGROUND: Objective and reliable outcome measures to facilitate clinical trials of novel treatments for systemic sclerosis (SSc)-related Raynaud's phenomenon (RP) are badly needed. Laser speckle contrast imaging (LSCI) and thermography are non-invasive measures of perfusion that show excellent potential. The purpose of this multi-centre study was to determine the reliability and validity of a hand cold challenge protocol using LSCI, standard thermography and low-cost mobile phone-based thermography.METHODS: Patients with RP secondary to SSc were recruited from 6 UK tertiary-SSc centres and underwent cold challenge on 2 consecutive days. Changes in cutaneous perfusion/temperature at each visit were imaged simultaneously using LSCI, standard and mobile phone thermography. Measurements included area under reperfusion/rewarming curve (AUC) and maximum perfusion/rewarming (MAX). Test-retest reliability was assessed using intraclass correlation coefficients (ICC). Estimated latent correlations assessed convergent validity of LSCI and thermography.RESULTS: 159 patients were recruited (84{\%} female, 77{\%} limited cutaneous, median age 63.3 years). LSCI and standard thermography both had substantial reliability, ICCs (95{\%}CI) for AUC were 0.67(0.54-0.76) and 0.68(0.58-0.80) respectively, and for MAX were 0.64(0.52-0.75) and 0.72(0.64-0.81) respectively. Very high latent correlations (95{\%} CI) were present for AUCs of LSCI and thermography [0.94(0.87-1.00)], and for AUCs of standard and mobile phone thermography [0.98(0.94-1.00)].CONCLUSION: This is the first multi-centre study examining reliability and validity of cold challenge using LSCI and thermography in patients with SSc-related RP. LSCI and thermography demonstrated good potential as outcome measures. LSCI, standard and mobile phone thermography had very high convergent validity. This article is protected by copyright. All rights reserved.",
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TY - JOUR

T1 - A multicentre study of validity and reliability of responses to hand cold challenge as measured by laser speckle contrast imaging and thermography

T2 - Arthritis & Rheumatology

AU - Wilkinson,Jack D

AU - Leggett,Sarah A

AU - Marjanovic,Elizabeth J

AU - Moore,Tonia L

AU - Allen,John

AU - Anderson,Marina E

AU - Britton,Jason

AU - Buch,Maya H

AU - Galdo,Francesco Del

AU - Denton,Christopher P

AU - Dinsdale,Graham

AU - Griffiths,Bridgett

AU - Hall,Frances

AU - Howell,Kevin

AU - MacDonald,Audrey

AU - McHugh,Neil J

AU - Manning,Joanne B

AU - Pauling,John D

AU - Roberts,Christopher

AU - Shipley,Jacqueline A

AU - Herrick,Ariane L

AU - Murray,Andrea K

N1 - This article is protected by copyright. All rights reserved.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - BACKGROUND: Objective and reliable outcome measures to facilitate clinical trials of novel treatments for systemic sclerosis (SSc)-related Raynaud's phenomenon (RP) are badly needed. Laser speckle contrast imaging (LSCI) and thermography are non-invasive measures of perfusion that show excellent potential. The purpose of this multi-centre study was to determine the reliability and validity of a hand cold challenge protocol using LSCI, standard thermography and low-cost mobile phone-based thermography.METHODS: Patients with RP secondary to SSc were recruited from 6 UK tertiary-SSc centres and underwent cold challenge on 2 consecutive days. Changes in cutaneous perfusion/temperature at each visit were imaged simultaneously using LSCI, standard and mobile phone thermography. Measurements included area under reperfusion/rewarming curve (AUC) and maximum perfusion/rewarming (MAX). Test-retest reliability was assessed using intraclass correlation coefficients (ICC). Estimated latent correlations assessed convergent validity of LSCI and thermography.RESULTS: 159 patients were recruited (84% female, 77% limited cutaneous, median age 63.3 years). LSCI and standard thermography both had substantial reliability, ICCs (95%CI) for AUC were 0.67(0.54-0.76) and 0.68(0.58-0.80) respectively, and for MAX were 0.64(0.52-0.75) and 0.72(0.64-0.81) respectively. Very high latent correlations (95% CI) were present for AUCs of LSCI and thermography [0.94(0.87-1.00)], and for AUCs of standard and mobile phone thermography [0.98(0.94-1.00)].CONCLUSION: This is the first multi-centre study examining reliability and validity of cold challenge using LSCI and thermography in patients with SSc-related RP. LSCI and thermography demonstrated good potential as outcome measures. LSCI, standard and mobile phone thermography had very high convergent validity. This article is protected by copyright. All rights reserved.

AB - BACKGROUND: Objective and reliable outcome measures to facilitate clinical trials of novel treatments for systemic sclerosis (SSc)-related Raynaud's phenomenon (RP) are badly needed. Laser speckle contrast imaging (LSCI) and thermography are non-invasive measures of perfusion that show excellent potential. The purpose of this multi-centre study was to determine the reliability and validity of a hand cold challenge protocol using LSCI, standard thermography and low-cost mobile phone-based thermography.METHODS: Patients with RP secondary to SSc were recruited from 6 UK tertiary-SSc centres and underwent cold challenge on 2 consecutive days. Changes in cutaneous perfusion/temperature at each visit were imaged simultaneously using LSCI, standard and mobile phone thermography. Measurements included area under reperfusion/rewarming curve (AUC) and maximum perfusion/rewarming (MAX). Test-retest reliability was assessed using intraclass correlation coefficients (ICC). Estimated latent correlations assessed convergent validity of LSCI and thermography.RESULTS: 159 patients were recruited (84% female, 77% limited cutaneous, median age 63.3 years). LSCI and standard thermography both had substantial reliability, ICCs (95%CI) for AUC were 0.67(0.54-0.76) and 0.68(0.58-0.80) respectively, and for MAX were 0.64(0.52-0.75) and 0.72(0.64-0.81) respectively. Very high latent correlations (95% CI) were present for AUCs of LSCI and thermography [0.94(0.87-1.00)], and for AUCs of standard and mobile phone thermography [0.98(0.94-1.00)].CONCLUSION: This is the first multi-centre study examining reliability and validity of cold challenge using LSCI and thermography in patients with SSc-related RP. LSCI and thermography demonstrated good potential as outcome measures. LSCI, standard and mobile phone thermography had very high convergent validity. This article is protected by copyright. All rights reserved.

KW - Journal Article

U2 - 10.1002/art.40457

DO - 10.1002/art.40457

M3 - Article

VL - 70

SP - 903

EP - 911

JO - Arthritis & Rheumatology

JF - Arthritis & Rheumatology

SN - 2326-5191

IS - 6

ER -