A multi-stakeholders perspective on how to improve psychological treatments for depression in young people

Victoria Pile, Georgia Herring, Alex Bullard, Maria Loades, Stella W. Y. Chan, Shirley Reynolds, Faith Orchard

Research output: Contribution to journalLetterpeer-review

19 Downloads (Pure)


Meta-analyses of the effectiveness of psychological treatments typically report standardized mean differences (SMD), which can be problematic as they do not necessarily translate into clinically significant change. Cuijpers et al.’s meta-analysis [1] reported instead on response and recovery rates, clinically significant change and deterioration. The meta-analysis found that only 39% of young people receiving psychotherapy for depression responded to treatment (defined by ≥ 50% symptom reduction) compared to 24% of those who did not receive psychotherapy. These sobering findings make it clear that innovative approaches are needed to reduce the personal and societal burden of depression.

Research could explore various avenues to generate more effective interventions, we believe that some of the most promising avenues include: developing interventions that target key mechanisms which drive and maintain depression [2]; better understanding who might benefit from which type of intervention [3]; and working with young people to design and implement new treatments [4]. More specific ‘key questions’ for research have also been outlined by several James Lind Alliance (JLA) priority-setting partnerships, which have been funded to co-develop priorities for depression research (e.g., https://www.jla.nihr.ac.uk/priority-setting-partnerships/depression/top-10-priorities/) and youth mental health research more broadly (https://mcpin.org/priorities-for-research-in-children-and-young-peoples-mental-health/). Here, we report on our approach to translating some of these priorities into meaningful future directions for research and clinical practice.
Original languageEnglish
Pages (from-to)2375-2378
JournalEuropean Child & Adolescent Psychiatry
Early online date11 May 2022
Publication statusPublished - 30 Nov 2023

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental and Educational Psychology
  • Psychiatry and Mental health


Dive into the research topics of 'A multi-stakeholders perspective on how to improve psychological treatments for depression in young people'. Together they form a unique fingerprint.

Cite this