A mouse informatics platform for phenotypic and translational discovery

Natalie Ring; Terrence F Meehan; Andrew Blake; James Brown; Chao-Kung Chen; Nathalie Conte; Armida Di Fenza; Tanja Fiegel; Neil Horner; Julius O B Jacobsen; Natasha Karp; Thomas Lawson; Jeremy C Mason; Peter Matthews; Hugh Morgan; Mike Relac; Luis Santos; Damian Smedley; Duncan Sneddon; Alice Pengelly; Ilinca Tudose; Jonathan W G Warren; Henrik Westerberg; Gagarine Yaikhom; Helen Parkinson; Ann-Marie Mallon

doi:10.1007/s00335-015-9599-2

A mouse informatics platform for phenotypic and translational discovery

Natalie Ring, Terrence F Meehan, Andrew Blake, James Brown, Chao-Kung Chen, Nathalie Conte, Armida Di Fenza, Tanja Fiegel, Neil Horner, Julius O B Jacobsen, Natasha Karp, Thomas Lawson, Jeremy C Mason, Peter Matthews, Hugh Morgan, Mike Relac, Luis Santos, Damian Smedley, Duncan Sneddon, Alice PengellyIlinca Tudose, Jonathan W G Warren, Henrik Westerberg, Gagarine Yaikhom, Helen Parkinson, Ann-Marie Mallon

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

22 Citations (SciVal)

Abstract

The International Mouse Phenotyping Consortium (IMPC) is providing the world's first functional catalogue of a mammalian genome by characterising a knockout mouse strain for every gene. A robust and highly structured informatics platform has been developed to systematically collate, analyse and disseminate the data produced by the IMPC. As the first phase of the project, in which 5000 new knockout strains are being broadly phenotyped, nears completion, the informatics platform is extending and adapting to support the increasing volume and complexity of the data produced as well as addressing a large volume of users and emerging user groups. An intuitive interface helps researchers explore IMPC data by giving overviews and the ability to find and visualise data that support a phenotype assertion. Dedicated disease pages allow researchers to find new mouse models of human diseases, and novel viewers provide high-resolution images of embryonic and adult dysmorphologies. With each monthly release, the informatics platform will continue to evolve to support the increased data volume and to maintain its position as the primary route of access to IMPC data and as an invaluable resource for clinical and non-clinical researchers.

Original language	English
Pages (from-to)	413-21
Number of pages	9
Journal	Mammalian Genome
Volume	26
Issue number	9-10
Early online date	28 Aug 2015
DOIs	https://doi.org/10.1007/s00335-015-9599-2
Publication status	Published - 1 Oct 2015

Keywords

Animals
Computational Biology
Genome
Humans
Mice
Mice, Inbred Strains/genetics
Mice, Knockout/genetics
Phenotype

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Ring, N., Meehan, T. F., Blake, A., Brown, J., Chen, C.-K., Conte, N., Di Fenza, A., Fiegel, T., Horner, N., Jacobsen, J. O. B., Karp, N., Lawson, T., Mason, J. C., Matthews, P., Morgan, H., Relac, M., Santos, L., Smedley, D., Sneddon, D., ... Mallon, A.-M. (2015). A mouse informatics platform for phenotypic and translational discovery. Mammalian Genome, 26(9-10), 413-21. https://doi.org/10.1007/s00335-015-9599-2

Ring, N, Meehan, TF, Blake, A, Brown, J, Chen, C-K, Conte, N, Di Fenza, A, Fiegel, T, Horner, N, Jacobsen, JOB, Karp, N, Lawson, T, Mason, JC, Matthews, P, Morgan, H, Relac, M, Santos, L, Smedley, D, Sneddon, D, Pengelly, A, Tudose, I, Warren, JWG, Westerberg, H, Yaikhom, G, Parkinson, H & Mallon, A-M 2015, 'A mouse informatics platform for phenotypic and translational discovery', Mammalian Genome, vol. 26, no. 9-10, pp. 413-21. https://doi.org/10.1007/s00335-015-9599-2

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AU - Di Fenza, Armida

AU - Fiegel, Tanja

AU - Horner, Neil

AU - Jacobsen, Julius O B

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AU - Morgan, Hugh

AU - Relac, Mike

AU - Santos, Luis

AU - Smedley, Damian

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AU - Pengelly, Alice

AU - Tudose, Ilinca

AU - Warren, Jonathan W G

AU - Westerberg, Henrik

AU - Yaikhom, Gagarine

AU - Parkinson, Helen

AU - Mallon, Ann-Marie

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KW - Mice

KW - Mice, Inbred Strains/genetics

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JO - Mammalian Genome

JF - Mammalian Genome

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A mouse informatics platform for phenotypic and translational discovery

Abstract

Keywords

UN SDGs

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