A molecular recognition platform for the simultaneous sensing of diverse chemical weapons

Lintao Zeng; Tianhong Chen; Beitong Zhu; Seyoung Koo; Yonghe Tang; Weiying Lin; Tony D. James; Jong Seung Kim

doi:10.1039/d2sc00299j

A molecular recognition platform for the simultaneous sensing of diverse chemical weapons

Lintao Zeng, Tianhong Chen, Beitong Zhu, Seyoung Koo, Yonghe Tang, Weiying Lin, Tony D. James, Jong Seung Kim

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

67 Citations (SciVal)

Abstract

Chemical warfare agents (CWAs) such as phosgene and nerve agents pose serious threats to our lives and public security, but no tools can simultaneously screen multiple CWAs in seconds. Here, we rationally designed a robust sensing platform based on 8-cyclohexanyldiamino-BODIPY (BODIPY-DCH) to monitor diverse CWAs in different emission channels. Trans-cyclohexanyldiamine as the reactive site provides optimal geometry and high reactivity, allowing trans-BODIPY-DCH to detect CWAs with a quick response and high sensitivity, while cis-BODIPY-DCH has much weaker reactivity to CWAs due to intramolecular H-bonding. Upon reaction with phosgene, trans-BODIPY-DCH was rapidly converted to imidazolone BODIPY (<3 s), triggering green fluorescence with good sensitivity (LOD = 0.52 nM). trans-BODIPY-DCH coupled with nerve agent mimics, affording a blue fluorescent 8-amino-BODIPY tautomer. Furthermore, a portable test kit using trans-BODIPY-DCH displayed an instant response and low detection limits for multiple CWAs. This platform enables rapid and highly sensitive visual screening of various CWAs.

Original language	English
Pages (from-to)	4523-4532
Journal	Chemical Science
Volume	13
Issue number	16
Early online date	23 Mar 2022
DOIs	https://doi.org/10.1039/d2sc00299j
Publication status	Published - 28 Apr 2022

Bibliographical note

Funding Information:
We appreciate the funding support from the National Natural Science Foundation of China (No. 22168009, 21978222, L. Z.; 21877048, and 22077048, W. L.; 22104019, Y. T.), the Natural Science Foundation of Guangxi (No. 2020GXNSFDA297030, 2021GXNSFDA075003, and 2019GXNSFBA245068), and the startup fund of Guangxi University (A3040051003 and A3050051005). This work was also supported by the National Research Foundation of Korea (NRF) (CRI Project No. 2018R1A3B1052702 and 2019M3E5D1A01068998, J. S. K.). T. D. J. wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01).

ASJC Scopus subject areas

General Chemistry

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10.1039/d2sc00299jLicence: CC BY

Cite this

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title = "A molecular recognition platform for the simultaneous sensing of diverse chemical weapons",

abstract = "Chemical warfare agents (CWAs) such as phosgene and nerve agents pose serious threats to our lives and public security, but no tools can simultaneously screen multiple CWAs in seconds. Here, we rationally designed a robust sensing platform based on 8-cyclohexanyldiamino-BODIPY (BODIPY-DCH) to monitor diverse CWAs in different emission channels. Trans-cyclohexanyldiamine as the reactive site provides optimal geometry and high reactivity, allowing trans-BODIPY-DCH to detect CWAs with a quick response and high sensitivity, while cis-BODIPY-DCH has much weaker reactivity to CWAs due to intramolecular H-bonding. Upon reaction with phosgene, trans-BODIPY-DCH was rapidly converted to imidazolone BODIPY (<3 s), triggering green fluorescence with good sensitivity (LOD = 0.52 nM). trans-BODIPY-DCH coupled with nerve agent mimics, affording a blue fluorescent 8-amino-BODIPY tautomer. Furthermore, a portable test kit using trans-BODIPY-DCH displayed an instant response and low detection limits for multiple CWAs. This platform enables rapid and highly sensitive visual screening of various CWAs.",

author = "Lintao Zeng and Tianhong Chen and Beitong Zhu and Seyoung Koo and Yonghe Tang and Weiying Lin and James, {Tony D.} and Kim, {Jong Seung}",

note = "Funding Information: We appreciate the funding support from the National Natural Science Foundation of China (No. 22168009, 21978222, L. Z.; 21877048, and 22077048, W. L.; 22104019, Y. T.), the Natural Science Foundation of Guangxi (No. 2020GXNSFDA297030, 2021GXNSFDA075003, and 2019GXNSFBA245068), and the startup fund of Guangxi University (A3040051003 and A3050051005). This work was also supported by the National Research Foundation of Korea (NRF) (CRI Project No. 2018R1A3B1052702 and 2019M3E5D1A01068998, J. S. K.). T. D. J. wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01). ",

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AU - Lin, Weiying

AU - James, Tony D.

AU - Kim, Jong Seung

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N2 - Chemical warfare agents (CWAs) such as phosgene and nerve agents pose serious threats to our lives and public security, but no tools can simultaneously screen multiple CWAs in seconds. Here, we rationally designed a robust sensing platform based on 8-cyclohexanyldiamino-BODIPY (BODIPY-DCH) to monitor diverse CWAs in different emission channels. Trans-cyclohexanyldiamine as the reactive site provides optimal geometry and high reactivity, allowing trans-BODIPY-DCH to detect CWAs with a quick response and high sensitivity, while cis-BODIPY-DCH has much weaker reactivity to CWAs due to intramolecular H-bonding. Upon reaction with phosgene, trans-BODIPY-DCH was rapidly converted to imidazolone BODIPY (<3 s), triggering green fluorescence with good sensitivity (LOD = 0.52 nM). trans-BODIPY-DCH coupled with nerve agent mimics, affording a blue fluorescent 8-amino-BODIPY tautomer. Furthermore, a portable test kit using trans-BODIPY-DCH displayed an instant response and low detection limits for multiple CWAs. This platform enables rapid and highly sensitive visual screening of various CWAs.

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A molecular recognition platform for the simultaneous sensing of diverse chemical weapons

Abstract

Bibliographical note

ASJC Scopus subject areas

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