A modular approach to catalytic synthesis using a dual-functional linker for Click and Suzuki coupling reactions

James R White; Gareth J Price; Stefanie Schiffers; Paul R Raithby; Pawel K Plucinski; Christopher G Frost

doi:10.1016/j.tetlet.2010.05.104

A modular approach to catalytic synthesis using a dual-functional linker for Click and Suzuki coupling reactions

James R White, Gareth J Price, Stefanie Schiffers, Paul R Raithby, Pawel K Plucinski, Christopher G Frost

Research output: Contribution to journal › Article › peer-review

26 Citations (SciVal)

Abstract

The stable benzylaziclo-boronate ester 1 is presented as an example of a dual-functional linker that allows the synthetically valuable boronate motif to be clicked onto other molecules under mild conditions. The utility of the azido-boronate motif as a modular building block is demonstrated in the rapid synthesis of drug-like structures employing sequential catalytic azide-alkyne cycloaddition and Suzuki coupling reactions.

Original language	English
Pages (from-to)	3913-3917
Number of pages	5
Journal	Tetrahedron Letters
Volume	51
Issue number	30
DOIs	https://doi.org/10.1016/j.tetlet.2010.05.104
Publication status	Published - 28 Jul 2010

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10.1016/j.tetlet.2010.05.104

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title = "A modular approach to catalytic synthesis using a dual-functional linker for Click and Suzuki coupling reactions",

abstract = "The stable benzylaziclo-boronate ester 1 is presented as an example of a dual-functional linker that allows the synthetically valuable boronate motif to be clicked onto other molecules under mild conditions. The utility of the azido-boronate motif as a modular building block is demonstrated in the rapid synthesis of drug-like structures employing sequential catalytic azide-alkyne cycloaddition and Suzuki coupling reactions.",

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AU - White, James R

AU - Price, Gareth J

AU - Schiffers, Stefanie

AU - Raithby, Paul R

AU - Plucinski, Pawel K

AU - Frost, Christopher G

PY - 2010/7/28

Y1 - 2010/7/28

N2 - The stable benzylaziclo-boronate ester 1 is presented as an example of a dual-functional linker that allows the synthetically valuable boronate motif to be clicked onto other molecules under mild conditions. The utility of the azido-boronate motif as a modular building block is demonstrated in the rapid synthesis of drug-like structures employing sequential catalytic azide-alkyne cycloaddition and Suzuki coupling reactions.

AB - The stable benzylaziclo-boronate ester 1 is presented as an example of a dual-functional linker that allows the synthetically valuable boronate motif to be clicked onto other molecules under mild conditions. The utility of the azido-boronate motif as a modular building block is demonstrated in the rapid synthesis of drug-like structures employing sequential catalytic azide-alkyne cycloaddition and Suzuki coupling reactions.

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UR - http://dx.doi.org/10.1016/j.tetlet.2010.05.104

U2 - 10.1016/j.tetlet.2010.05.104

DO - 10.1016/j.tetlet.2010.05.104

M3 - Article

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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ER -

A modular approach to catalytic synthesis using a dual-functional linker for Click and Suzuki coupling reactions

Abstract

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A Flow Process for Aminomethylations using Catalysts Supported on Magnetic Nanoparticles

ENGINEERING FUNCTIONAL MATERIALS FOR CATALYTIC SMART MICRORE ACTORS

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A modular approach to catalytic synthesis using a dual-functional linker for Click and Suzuki coupling reactions

Abstract

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A Flow Process for Aminomethylations using Catalysts Supported on Magnetic Nanoparticles

ENGINEERING FUNCTIONAL MATERIALS FOR CATALYTIC SMART MICRORE ACTORS

Cite this