A modular approach to catalytic synthesis using a dual-functional linker for Click and Suzuki coupling reactions

James R White, Gareth J Price, Stefanie Schiffers, Paul R Raithby, Pawel K Plucinski, Christopher G Frost

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The stable benzylaziclo-boronate ester 1 is presented as an example of a dual-functional linker that allows the synthetically valuable boronate motif to be clicked onto other molecules under mild conditions. The utility of the azido-boronate motif as a modular building block is demonstrated in the rapid synthesis of drug-like structures employing sequential catalytic azide-alkyne cycloaddition and Suzuki coupling reactions.
Original languageEnglish
Pages (from-to)3913-3917
Number of pages5
JournalTetrahedron Letters
Volume51
Issue number30
DOIs
Publication statusPublished - 28 Jul 2010

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  • Projects

  • ENGINEERING FUNCTIONAL MATERIALS FOR CATALYTIC SMART MICRORE ACTORS

    Plucinski, P., Frost, C., Lapkin, A. & Price, G.

    Engineering and Physical Sciences Research Council

    1/10/0631/03/10

    Project: Research council

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