A modular approach to catalytic synthesis using a dual-functional linker for Click and Suzuki coupling reactions

James R White, Gareth J Price, Stefanie Schiffers, Paul R Raithby, Pawel K Plucinski, Christopher G Frost

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

The stable benzylaziclo-boronate ester 1 is presented as an example of a dual-functional linker that allows the synthetically valuable boronate motif to be clicked onto other molecules under mild conditions. The utility of the azido-boronate motif as a modular building block is demonstrated in the rapid synthesis of drug-like structures employing sequential catalytic azide-alkyne cycloaddition and Suzuki coupling reactions.
Original languageEnglish
Pages (from-to)3913-3917
Number of pages5
JournalTetrahedron Letters
Volume51
Issue number30
DOIs
Publication statusPublished - 28 Jul 2010

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