A modular approach to catalytic synthesis using a dual-functional linker for Click and Suzuki coupling reactions

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The stable benzylaziclo-boronate ester 1 is presented as an example of a dual-functional linker that allows the synthetically valuable boronate motif to be clicked onto other molecules under mild conditions. The utility of the azido-boronate motif as a modular building block is demonstrated in the rapid synthesis of drug-like structures employing sequential catalytic azide-alkyne cycloaddition and Suzuki coupling reactions.
Original languageEnglish
Pages (from-to)3913-3917
Number of pages5
JournalTetrahedron Letters
Volume51
Issue number30
DOIs
Publication statusPublished - 28 Jul 2010

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Alkynes
Azides
Cycloaddition
Cycloaddition Reaction
Esters
Molecules
Pharmaceutical Preparations

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A modular approach to catalytic synthesis using a dual-functional linker for Click and Suzuki coupling reactions. / White, James R; Price, Gareth J; Schiffers, Stefanie; Raithby, Paul R; Plucinski, Pawel K; Frost, Christopher G.

In: Tetrahedron Letters, Vol. 51, No. 30, 28.07.2010, p. 3913-3917.

Research output: Contribution to journalArticle

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