A mild hydration of nitriles catalysed by copper(ii) acetate

Patricia Marcé; James Lynch; A. John Blacker; Jonathan M.  J. Williams

doi:10.1039/c5cc08714g

A mild hydration of nitriles catalysed by copper(ii) acetate

Patricia Marcé
, James Lynch
, A. John Blacker
, Jonathan M. J. Williams

University of Leeds

Research output: Contribution to journal › Article › peer-review

71 Citations (SciVal)

Abstract

A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N,N-diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields.

Original language	English
Pages (from-to)	1436-1438
Number of pages	3
Journal	Chemical Communications
Volume	52
Issue number	7
Early online date	20 Nov 2015
DOIs	https://doi.org/10.1039/c5cc08714g
Publication status	Published - 25 Jan 2016

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10.1039/c5cc08714g

http://dx.doi.org/10.1039/c5cc08714g

Cite this

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title = "A mild hydration of nitriles catalysed by copper(ii) acetate",

abstract = "A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N,N-diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields.",

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AU - Marcé, Patricia

AU - Lynch, James

AU - Blacker, A. John

AU - Williams, Jonathan M. J.

PY - 2016/1/25

Y1 - 2016/1/25

N2 - A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N,N-diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields.

AB - A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N,N-diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields.

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UR - http://dx.doi.org/10.1039/c5cc08714g

U2 - 10.1039/c5cc08714g

DO - 10.1039/c5cc08714g

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VL - 52

SP - 1436

EP - 1438

JO - Chemical Communications

JF - Chemical Communications

IS - 7

ER -

A mild hydration of nitriles catalysed by copper(ii) acetate

Abstract

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New Generic Synthetic Protocols for Pharmaceutical Intermediates

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A mild hydration of nitriles catalysed by copper(ii) acetate

Abstract

Access to Document

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The UK Catalysis Hub

New Generic Synthetic Protocols for Pharmaceutical Intermediates

Cite this