Abstract
A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N,N-diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields.
| Original language | English |
|---|---|
| Pages (from-to) | 1436-1438 |
| Number of pages | 3 |
| Journal | Chemical Communications |
| Volume | 52 |
| Issue number | 7 |
| Early online date | 20 Nov 2015 |
| DOIs | |
| Publication status | Published - 25 Jan 2016 |
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Cite this
Marcé, P., Lynch, J., Blacker, A. J., & Williams, J. M. J. (2016). A mild hydration of nitriles catalysed by copper(ii) acetate. Chemical Communications, 52(7), 1436-1438. https://doi.org/10.1039/c5cc08714g