A mild hydration of nitriles catalysed by copper(ii) acetate

Patricia Marcé; James Lynch; A. John Blacker; Jonathan M.  J. Williams

doi:10.1039/c5cc08714g

A mild hydration of nitriles catalysed by copper(ii) acetate

Patricia Marcé, James Lynch, A. John Blacker, Jonathan M. J. Williams

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N,N-diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields.

Original language	English
Pages (from-to)	1436-1438
Number of pages	3
Journal	Chemical Communications
Volume	52
Issue number	7
Early online date	20 Nov 2015
DOIs	https://doi.org/10.1039/c5cc08714g
Publication status	Published - 25 Jan 2016

Access to Document

10.1039/c5cc08714g

Fingerprint Dive into the research topics of 'A mild hydration of nitriles catalysed by copper(ii) acetate'. Together they form a unique fingerprint.

Cite this

@article{89bca11219254b7db36628572989f159,

title = "A mild hydration of nitriles catalysed by copper(ii) acetate",

abstract = "A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N,N-diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields.",

author = "Patricia Marc{\'e} and James Lynch and Blacker, {A. John} and Williams, {Jonathan M. J.}",

year = "2016",

month = jan,

day = "25",

doi = "10.1039/c5cc08714g",

language = "English",

volume = "52",

pages = "1436--1438",

journal = "Chemical communications (Cambridge, England)",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "7",

}

TY - JOUR

T1 - A mild hydration of nitriles catalysed by copper(ii) acetate

AU - Marcé, Patricia

AU - Lynch, James

AU - Blacker, A. John

AU - Williams, Jonathan M. J.

PY - 2016/1/25

Y1 - 2016/1/25

N2 - A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N,N-diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields.

AB - A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N,N-diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields.

UR - http://www.scopus.com/inward/record.url?scp=84954408112&partnerID=8YFLogxK

UR - http://dx.doi.org/10.1039/c5cc08714g

U2 - 10.1039/c5cc08714g

DO - 10.1039/c5cc08714g

M3 - Article

AN - SCOPUS:84954408112

VL - 52

SP - 1436

EP - 1438

JO - Chemical communications (Cambridge, England)

JF - Chemical communications (Cambridge, England)

SN - 1359-7345

IS - 7

ER -