A mild hydration of nitriles catalysed by copper(ii) acetate

Patricia Marcé, James Lynch, A. John Blacker, Jonathan M. J. Williams

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N,N-diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields.

Original languageEnglish
Pages (from-to)1436-1438
Number of pages3
JournalChemical Communications
Volume52
Issue number7
Early online date20 Nov 2015
DOIs
Publication statusPublished - 25 Jan 2016

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    Marcé, P., Lynch, J., Blacker, A. J., & Williams, J. M. J. (2016). A mild hydration of nitriles catalysed by copper(ii) acetate. Chemical Communications, 52(7), 1436-1438. https://doi.org/10.1039/c5cc08714g