A mild hydration of nitriles catalysed by copper(ii) acetate

Patricia Marcé; James Lynch; A. John Blacker; Jonathan M.  J. Williams

doi:10.1039/c5cc08714g

A mild hydration of nitriles catalysed by copper(ii) acetate

Patricia Marcé, James Lynch, A. John Blacker, Jonathan M. J. Williams

University of Leeds

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64 Citations (SciVal)

Abstract

A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N,N-diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields.

Original language	English
Pages (from-to)	1436-1438
Number of pages	3
Journal	Chemical Communications
Volume	52
Issue number	7
Early online date	20 Nov 2015
DOIs	https://doi.org/10.1039/c5cc08714g
Publication status	Published - 25 Jan 2016

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10.1039/c5cc08714g

http://dx.doi.org/10.1039/c5cc08714g

Cite this

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title = "A mild hydration of nitriles catalysed by copper(ii) acetate",

abstract = "A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N,N-diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields.",

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AU - Williams, Jonathan M. J.

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AB - A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N,N-diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields.

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A mild hydration of nitriles catalysed by copper(ii) acetate

Abstract

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New Generic Synthetic Protocols for Pharmaceutical Intermediates

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A mild hydration of nitriles catalysed by copper(ii) acetate

Abstract

Access to Document

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The UK Catalysis Hub

New Generic Synthetic Protocols for Pharmaceutical Intermediates

Cite this