Abstract
A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N,N-diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields.
Original language | English |
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Pages (from-to) | 1436-1438 |
Number of pages | 3 |
Journal | Chemical Communications |
Volume | 52 |
Issue number | 7 |
Early online date | 20 Nov 2015 |
DOIs | |
Publication status | Published - 25 Jan 2016 |