TY - JOUR
T1 - A mild, copper-catalysed amide deprotection strategy
T2 - use of tert-butyl as a protecting group
AU - Evans, Vikki
AU - Mahon, M F
AU - Webster, R L
PY - 2014/10/14
Y1 - 2014/10/14
N2 - Mild methods for the deprotection of organic substrates are of fundamental importance in synthetic chemistry. A new room temperature method using a catalytic amount of Cu(OTf)2 is reported. This allows use of the tert-butyl group as an amide protecting group. The methodology is also extended to Boc-deprotection.
AB - Mild methods for the deprotection of organic substrates are of fundamental importance in synthetic chemistry. A new room temperature method using a catalytic amount of Cu(OTf)2 is reported. This allows use of the tert-butyl group as an amide protecting group. The methodology is also extended to Boc-deprotection.
UR - http://www.sciencedirect.com/science/article/pii/S0040402014011090
UR - http://dx.doi.org/10.1016/j.tet.2014.07.080
U2 - 10.1016/j.tet.2014.07.080
DO - 10.1016/j.tet.2014.07.080
M3 - Article
VL - 70
SP - 7593
EP - 7597
JO - Tetrahedron
JF - Tetrahedron
SN - 0040-4020
IS - 41
ER -