A mild, copper-catalysed amide deprotection strategy: use of tert-butyl as a protecting group

Vikki Evans, M F Mahon, R L Webster

Research output: Contribution to journalArticle

10 Citations (Scopus)
449 Downloads (Pure)

Abstract

Mild methods for the deprotection of organic substrates are of fundamental importance in synthetic chemistry. A new room temperature method using a catalytic amount of Cu(OTf)2 is reported. This allows use of the tert-butyl group as an amide protecting group. The methodology is also extended to Boc-deprotection.
Original languageEnglish
Pages (from-to)7593-7597
Number of pages5
JournalTetrahedron
Volume70
Issue number41
DOIs
Publication statusPublished - 14 Oct 2014

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