A mild Boc deprotection and the importance of a free carboxylate

Ali Thaqi; Adam McCluskey; Janet L. Scott

doi:10.1016/j.tetlet.2008.09.027

A mild Boc deprotection and the importance of a free carboxylate

Ali Thaqi, Adam McCluskey, Janet L. Scott

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26 Citations (SciVal)

Abstract

We report a facile and rapid removal of Boc protecting groups using microwave heating in H2O, with deprotection only requiring a free carboxylic acid group in the starting material. Unlike previous approaches, no additional reagents are required.

Original language	English
Pages (from-to)	6962-6964
Journal	Tetrahedron Letters
Volume	49
Issue number	49
DOIs	https://doi.org/10.1016/j.tetlet.2008.09.027
Publication status	Published - 1 Dec 2008

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10.1016/j.tetlet.2008.09.027

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title = "A mild Boc deprotection and the importance of a free carboxylate",

abstract = "We report a facile and rapid removal of Boc protecting groups using microwave heating in H2O, with deprotection only requiring a free carboxylic acid group in the starting material. Unlike previous approaches, no additional reagents are required.",

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AU - Thaqi, Ali

AU - McCluskey, Adam

AU - Scott, Janet L.

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N2 - We report a facile and rapid removal of Boc protecting groups using microwave heating in H2O, with deprotection only requiring a free carboxylic acid group in the starting material. Unlike previous approaches, no additional reagents are required.

AB - We report a facile and rapid removal of Boc protecting groups using microwave heating in H2O, with deprotection only requiring a free carboxylic acid group in the starting material. Unlike previous approaches, no additional reagents are required.

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UR - http://dx.doi.org/10.1016/j.tetlet.2008.09.027

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DO - 10.1016/j.tetlet.2008.09.027

M3 - Article

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VL - 49

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 49

ER -

A mild Boc deprotection and the importance of a free carboxylate

Abstract

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