A mathematical model for cell population kinetics in the intestine

N. F. Britton; N. A. Wright; J. D. Murray

doi:10.1016/0022-5193(82)90135-7

A mathematical model for cell population kinetics in the intestine

N. F. Britton, N. A. Wright, J. D. Murray

Research output: Contribution to journal › Article › peer-review

Abstract

A compartmental model for the cell populations in the intestine is set up. The results obtained are compared with experimental data in the mouse. It is shown that chemical feedback from the villus cells to the crypt together with a self-regulatory mechanism for the stem cells is sufficient to explain the reaction of the villus cell population which is observed after a cytotoxic insult to the crypt cells.

Original language	English
Pages (from-to)	531-541
Number of pages	11
Journal	Journal of Theoretical Biology
Volume	98
Issue number	3
DOIs	https://doi.org/10.1016/0022-5193(82)90135-7
Publication status	Published - 7 Oct 1982

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title = "A mathematical model for cell population kinetics in the intestine",

abstract = "A compartmental model for the cell populations in the intestine is set up. The results obtained are compared with experimental data in the mouse. It is shown that chemical feedback from the villus cells to the crypt together with a self-regulatory mechanism for the stem cells is sufficient to explain the reaction of the villus cell population which is observed after a cytotoxic insult to the crypt cells.",

author = "Britton, {N. F.} and Wright, {N. A.} and Murray, {J. D.}",

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AB - A compartmental model for the cell populations in the intestine is set up. The results obtained are compared with experimental data in the mouse. It is shown that chemical feedback from the villus cells to the crypt together with a self-regulatory mechanism for the stem cells is sufficient to explain the reaction of the villus cell population which is observed after a cytotoxic insult to the crypt cells.

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A mathematical model for cell population kinetics in the intestine

Abstract

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