A compartmental model for the cell populations in the intestine is set up. The results obtained are compared with experimental data in the mouse. It is shown that chemical feedback from the villus cells to the crypt together with a self-regulatory mechanism for the stem cells is sufficient to explain the reaction of the villus cell population which is observed after a cytotoxic insult to the crypt cells.

Original languageEnglish
Pages (from-to)531-541
Number of pages11
JournalJournal of Theoretical Biology
Issue number3
Publication statusPublished - 7 Oct 1982


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