A longitudinal analysis of prevalence of sustained remission and low disease activity in rheumatoid arthritis patients treated with anti-tumour necrosis factor: an analysis of the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis

Philip D H Hamann, Gavin Shaddick, Neil McHugh, Kimme Hyrich, John D Pauling

Research output: Contribution to journalMeeting abstract

Abstract

Background: Attainment of remission or low disease activity (LDA) are recommended targets for rheumatoid arthritis (RA) treatment, and associated with improved functional and radiographic long-term outcomes. However, evidence reporting the prevalence of sustained remission/LDA is sparse. This study examines how often sustained remission/LDA occurs, and how this outcome has changed between 2001 and 2013 in patients with RA treated with anti-tumour necrosis factor (TNF) using data from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis (BSRBR-RA).Methods: Data were included on all RA patients treated with their first anti-TNF agent between 2001 and 2013 and censored following discontinuation of anti-TNF/switching biologic. The cohort was split into subgroups: patients commenced on anti-TNF between 2001-2010 and 2010-2013. Changes in prevalence of sustained remission/LDA were examined. Sustained remission/LDA was defined as a DAS28-ESR score of ≤ 2.6/≤3.2 for ≥6 months while on anti-TNF treatment. Data were censored at 3 years. Multiple imputation was used for missing data.
LanguageEnglish
Article number086
Number of pages1
JournalRheumatology
Volume57
Issue numbersuppl_3
Early online date25 Apr 2018
DOIs
StatusPublished - 30 Apr 2018

Cite this

@article{2fec6d4b04094b9f956f48f8624fed6f,
title = "A longitudinal analysis of prevalence of sustained remission and low disease activity in rheumatoid arthritis patients treated with anti-tumour necrosis factor: an analysis of the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis",
abstract = "Background: Attainment of remission or low disease activity (LDA) are recommended targets for rheumatoid arthritis (RA) treatment, and associated with improved functional and radiographic long-term outcomes. However, evidence reporting the prevalence of sustained remission/LDA is sparse. This study examines how often sustained remission/LDA occurs, and how this outcome has changed between 2001 and 2013 in patients with RA treated with anti-tumour necrosis factor (TNF) using data from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis (BSRBR-RA).Methods: Data were included on all RA patients treated with their first anti-TNF agent between 2001 and 2013 and censored following discontinuation of anti-TNF/switching biologic. The cohort was split into subgroups: patients commenced on anti-TNF between 2001-2010 and 2010-2013. Changes in prevalence of sustained remission/LDA were examined. Sustained remission/LDA was defined as a DAS28-ESR score of ≤ 2.6/≤3.2 for ≥6 months while on anti-TNF treatment. Data were censored at 3 years. Multiple imputation was used for missing data.",
author = "Hamann, {Philip D H} and Gavin Shaddick and Neil McHugh and Kimme Hyrich and Pauling, {John D}",
year = "2018",
month = "4",
day = "30",
doi = "10.1093/rheumatology/key075.310",
language = "English",
volume = "57",
journal = "Rheumatology",
issn = "1462-0324",
publisher = "Oxford University Press",
number = "suppl_3",

}

TY - JOUR

T1 - A longitudinal analysis of prevalence of sustained remission and low disease activity in rheumatoid arthritis patients treated with anti-tumour necrosis factor: an analysis of the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis

AU - Hamann, Philip D H

AU - Shaddick, Gavin

AU - McHugh, Neil

AU - Hyrich, Kimme

AU - Pauling, John D

PY - 2018/4/30

Y1 - 2018/4/30

N2 - Background: Attainment of remission or low disease activity (LDA) are recommended targets for rheumatoid arthritis (RA) treatment, and associated with improved functional and radiographic long-term outcomes. However, evidence reporting the prevalence of sustained remission/LDA is sparse. This study examines how often sustained remission/LDA occurs, and how this outcome has changed between 2001 and 2013 in patients with RA treated with anti-tumour necrosis factor (TNF) using data from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis (BSRBR-RA).Methods: Data were included on all RA patients treated with their first anti-TNF agent between 2001 and 2013 and censored following discontinuation of anti-TNF/switching biologic. The cohort was split into subgroups: patients commenced on anti-TNF between 2001-2010 and 2010-2013. Changes in prevalence of sustained remission/LDA were examined. Sustained remission/LDA was defined as a DAS28-ESR score of ≤ 2.6/≤3.2 for ≥6 months while on anti-TNF treatment. Data were censored at 3 years. Multiple imputation was used for missing data.

AB - Background: Attainment of remission or low disease activity (LDA) are recommended targets for rheumatoid arthritis (RA) treatment, and associated with improved functional and radiographic long-term outcomes. However, evidence reporting the prevalence of sustained remission/LDA is sparse. This study examines how often sustained remission/LDA occurs, and how this outcome has changed between 2001 and 2013 in patients with RA treated with anti-tumour necrosis factor (TNF) using data from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis (BSRBR-RA).Methods: Data were included on all RA patients treated with their first anti-TNF agent between 2001 and 2013 and censored following discontinuation of anti-TNF/switching biologic. The cohort was split into subgroups: patients commenced on anti-TNF between 2001-2010 and 2010-2013. Changes in prevalence of sustained remission/LDA were examined. Sustained remission/LDA was defined as a DAS28-ESR score of ≤ 2.6/≤3.2 for ≥6 months while on anti-TNF treatment. Data were censored at 3 years. Multiple imputation was used for missing data.

U2 - 10.1093/rheumatology/key075.310

DO - 10.1093/rheumatology/key075.310

M3 - Meeting abstract

VL - 57

JO - Rheumatology

T2 - Rheumatology

JF - Rheumatology

SN - 1462-0324

IS - suppl_3

M1 - 086

ER -