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Chemoselective ligation, including “click” chemistry, has found wide utility in general synthetic strategies and the specific modification of polymers and biomolecules. This has resulted in a number of applications of such approaches, particularly in the biomedical area, including diagnostic imaging and drug delivery. However, tools to chemoselectively decorate target molecules with multiple copies of a particular drug, ligand or label are lacking. We describe the design and synthesis of a hydrazide-anchored dendron scaffold for chemoselective ligation to carbonyl moieties, and demonstrate its use in the modification of aldehyde-rich surfaces with the RGD integrin-binding ligand.
O'Donovan, L., & De Bank, P. (2014). A hydrazide-anchored dendron scaffold for chemoselective ligation strategies. Organic and Biomolecular Chemistry, 12(37), 7290-7296. https://doi.org/10.1039/C4OB00870G