A hydrazide-anchored dendron scaffold for chemoselective ligation strategies

Liz O'Donovan, Paul De Bank

Research output: Contribution to journalArticle

4 Citations (Scopus)
129 Downloads (Pure)

Abstract

Chemoselective ligation, including “click” chemistry, has found wide utility in general synthetic strategies and the specific modification of polymers and biomolecules. This has resulted in a number of applications of such approaches, particularly in the biomedical area, including diagnostic imaging and drug delivery. However, tools to chemoselectively decorate target molecules with multiple copies of a particular drug, ligand or label are lacking. We describe the design and synthesis of a hydrazide-anchored dendron scaffold for chemoselective ligation to carbonyl moieties, and demonstrate its use in the modification of aldehyde-rich surfaces with the RGD integrin-binding ligand.
Original languageEnglish
Pages (from-to)7290-7296
Number of pages7
JournalOrganic and Biomolecular Chemistry
Volume12
Issue number37
Early online date4 Aug 2014
DOIs
Publication statusPublished - 7 Oct 2014

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