Projects per year
Abstract
Chemoselective ligation, including “click” chemistry, has found wide utility in general synthetic strategies and the specific modification of polymers and biomolecules. This has resulted in a number of applications of such approaches, particularly in the biomedical area, including diagnostic imaging and drug delivery. However, tools to chemoselectively decorate target molecules with multiple copies of a particular drug, ligand or label are lacking. We describe the design and synthesis of a hydrazide-anchored dendron scaffold for chemoselective ligation to carbonyl moieties, and demonstrate its use in the modification of aldehyde-rich surfaces with the RGD integrin-binding ligand.
Original language | English |
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Pages (from-to) | 7290-7296 |
Number of pages | 7 |
Journal | Organic and Biomolecular Chemistry |
Volume | 12 |
Issue number | 37 |
Early online date | 4 Aug 2014 |
DOIs | |
Publication status | Published - 7 Oct 2014 |
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Dive into the research topics of 'A hydrazide-anchored dendron scaffold for chemoselective ligation strategies'. Together they form a unique fingerprint.Projects
- 1 Finished
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Photopatterned Dendrons for Tissue Engineering
De Bank, P. (PI)
Engineering and Physical Sciences Research Council
1/10/09 → 30/09/12
Project: Research council
Profiles
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Paul De Bank
- Department of Life Sciences - Senior Lecturer
- Centre for Therapeutic Innovation
- Bath Institute for the Augmented Human
- Centre for Bioengineering & Biomedical Technologies (CBio)
- Centre for Integrated Materials, Processes & Structures (IMPS)
Person: Research & Teaching, Affiliate staff
Equipment
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Avance III 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (9West)
Material and Chemical Characterisation (MC2)Facility/equipment: Equipment
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Avance III 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer (9West)
Material and Chemical Characterisation (MC2)Facility/equipment: Equipment
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MC2-Mass Spectrometry (MS)
Material and Chemical Characterisation (MC2)Facility/equipment: Technology type