A high-density YAC contig map of human chromosome 22

J E Collins, C G Cole, L J Smink, C L Garrett, M A Leversha, C A Soderlund, G L Maslen, L A Everett, K M Rice, A J Coffey, S G Gregory, R Gwilliam, A Dunham, A F Davies, S Hassock, Christopher Todd, H Lehrach, T J M Hulsebos, J Weissenbach, B MorrowR S Kucherlapati, R Wadey, P Scambler, U-J Kim, M I Simon, M Peyard, Y-G Xie, N P Carter, R Durbin, J P Dumanski, D R Bentley, I Dunham

Research output: Contribution to journalArticle


We have constructed a high-resolution clone map of human chromosome 22 which integrates the available physical and genetic information, establishing a single consensus. The map consists of all classes of DNA landmarks ordered on 705 yeast artificial chromosomes (YACs) at an average landmark density of more than one per 70 kilobases. This map represents the practical limits of currently available YAC resources and provides the basis for determination of the entire gene content and genomic DNA sequence of human chromosome 22.

Original languageEnglish
Pages (from-to)367-79
Number of pages13
Issue number6547 Suppl
Publication statusPublished - 28 Sep 1995


  • Chromosome Mapping
  • Chromosomes, Artificial, Yeast
  • Chromosomes, Human, Pair 22
  • Genetic Markers
  • Humans
  • Sequence Tagged Sites

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    Collins, J. E., Cole, C. G., Smink, L. J., Garrett, C. L., Leversha, M. A., Soderlund, C. A., Maslen, G. L., Everett, L. A., Rice, K. M., Coffey, A. J., G Gregory, S., Gwilliam, R., Dunham, A., Davies, A. F., Hassock, S., Todd, C., Lehrach, H., Hulsebos, T. J. M., Weissenbach, J., ... Dunham, I. (1995). A high-density YAC contig map of human chromosome 22. Nature, 377(6547 Suppl), 367-79. https://doi.org/10.1038/377367a0