A high-density YAC contig map of human chromosome 22

J E Collins, C G Cole, L J Smink, C L Garrett, M A Leversha, C A Soderlund, G L Maslen, L A Everett, K M Rice, A J Coffey, S G Gregory, R Gwilliam, A Dunham, A F Davies, S Hassock, Christopher Todd, H Lehrach, T J M Hulsebos, J Weissenbach, B MorrowR S Kucherlapati, R Wadey, P Scambler, U-J Kim, M I Simon, M Peyard, Y-G Xie, N P Carter, R Durbin, J P Dumanski, D R Bentley, I Dunham

Research output: Contribution to journalArticle

Abstract

We have constructed a high-resolution clone map of human chromosome 22 which integrates the available physical and genetic information, establishing a single consensus. The map consists of all classes of DNA landmarks ordered on 705 yeast artificial chromosomes (YACs) at an average landmark density of more than one per 70 kilobases. This map represents the practical limits of currently available YAC resources and provides the basis for determination of the entire gene content and genomic DNA sequence of human chromosome 22.

Original languageEnglish
Pages (from-to)367-79
Number of pages13
JournalNature
Volume377
Issue number6547 Suppl
DOIs
Publication statusPublished - 28 Sep 1995

Keywords

  • Chromosome Mapping
  • Chromosomes, Artificial, Yeast
  • Chromosomes, Human, Pair 22
  • Genetic Markers
  • Humans
  • Sequence Tagged Sites

Fingerprint Dive into the research topics of 'A high-density YAC contig map of human chromosome 22'. Together they form a unique fingerprint.

  • Cite this

    Collins, J. E., Cole, C. G., Smink, L. J., Garrett, C. L., Leversha, M. A., Soderlund, C. A., Maslen, G. L., Everett, L. A., Rice, K. M., Coffey, A. J., G Gregory, S., Gwilliam, R., Dunham, A., Davies, A. F., Hassock, S., Todd, C., Lehrach, H., Hulsebos, T. J. M., Weissenbach, J., ... Dunham, I. (1995). A high-density YAC contig map of human chromosome 22. Nature, 377(6547 Suppl), 367-79. https://doi.org/10.1038/377367a0