A high-density YAC contig map of human chromosome 22

J E Collins; C G Cole; L J Smink; C L Garrett; M A Leversha; C A Soderlund; G L Maslen; L A Everett; K M Rice; A J Coffey; S G Gregory; R Gwilliam; A Dunham; A F Davies; S Hassock; Christopher Todd; H Lehrach; T J M Hulsebos; J Weissenbach; B Morrow; R S Kucherlapati; R Wadey; P Scambler; U-J Kim; M I Simon; M Peyard; Y-G Xie; N P Carter; R Durbin; J P Dumanski; D R Bentley; I Dunham

doi:10.1038/377367a0

A high-density YAC contig map of human chromosome 22

J E Collins, C G Cole, L J Smink, C L Garrett, M A Leversha, C A Soderlund, G L Maslen, L A Everett, K M Rice, A J Coffey, S G Gregory, R Gwilliam, A Dunham, A F Davies, S Hassock, Christopher Todd, H Lehrach, T J M Hulsebos, J Weissenbach, B MorrowR S Kucherlapati, R Wadey, P Scambler, U-J Kim, M I Simon, M Peyard, Y-G Xie, N P Carter, R Durbin, J P Dumanski, D R Bentley, I Dunham

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

We have constructed a high-resolution clone map of human chromosome 22 which integrates the available physical and genetic information, establishing a single consensus. The map consists of all classes of DNA landmarks ordered on 705 yeast artificial chromosomes (YACs) at an average landmark density of more than one per 70 kilobases. This map represents the practical limits of currently available YAC resources and provides the basis for determination of the entire gene content and genomic DNA sequence of human chromosome 22.

Original language	English
Pages (from-to)	367-79
Number of pages	13
Journal	Nature
Volume	377
Issue number	6547 Suppl
DOIs	https://doi.org/10.1038/377367a0
Publication status	Published - 28 Sept 1995

Keywords

Chromosome Mapping
Chromosomes, Artificial, Yeast
Chromosomes, Human, Pair 22
Genetic Markers
Humans
Sequence Tagged Sites

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10.1038/377367a0

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Collins, J. E., Cole, C. G., Smink, L. J., Garrett, C. L., Leversha, M. A., Soderlund, C. A., Maslen, G. L., Everett, L. A., Rice, K. M., Coffey, A. J., G Gregory, S., Gwilliam, R., Dunham, A., Davies, A. F., Hassock, S., Todd, C., Lehrach, H., Hulsebos, T. J. M., Weissenbach, J., ... Dunham, I. (1995). A high-density YAC contig map of human chromosome 22. Nature, 377(6547 Suppl), 367-79. https://doi.org/10.1038/377367a0

Collins, JE, Cole, CG, Smink, LJ, Garrett, CL, Leversha, MA, Soderlund, CA, Maslen, GL, Everett, LA, Rice, KM, Coffey, AJ, G Gregory, S, Gwilliam, R, Dunham, A, Davies, AF, Hassock, S, Todd, C, Lehrach, H, Hulsebos, TJM, Weissenbach, J, Morrow, B, Kucherlapati, RS, Wadey, R, Scambler, P, Kim, U-J, Simon, MI, Peyard, M, Xie, Y-G, Carter, NP, Durbin, R, Dumanski, JP, Bentley, DR & Dunham, I 1995, 'A high-density YAC contig map of human chromosome 22', Nature, vol. 377, no. 6547 Suppl, pp. 367-79. https://doi.org/10.1038/377367a0

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title = "A high-density YAC contig map of human chromosome 22",

abstract = "We have constructed a high-resolution clone map of human chromosome 22 which integrates the available physical and genetic information, establishing a single consensus. The map consists of all classes of DNA landmarks ordered on 705 yeast artificial chromosomes (YACs) at an average landmark density of more than one per 70 kilobases. This map represents the practical limits of currently available YAC resources and provides the basis for determination of the entire gene content and genomic DNA sequence of human chromosome 22.",

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T1 - A high-density YAC contig map of human chromosome 22

AU - Collins, J E

AU - Cole, C G

AU - Smink, L J

AU - Garrett, C L

AU - Leversha, M A

AU - Soderlund, C A

AU - Maslen, G L

AU - Everett, L A

AU - Rice, K M

AU - Coffey, A J

AU - G Gregory, S

AU - Gwilliam, R

AU - Dunham, A

AU - Davies, A F

AU - Hassock, S

AU - Todd, Christopher

AU - Lehrach, H

AU - Hulsebos, T J M

AU - Weissenbach, J

AU - Morrow, B

AU - Kucherlapati, R S

AU - Wadey, R

AU - Scambler, P

AU - Kim, U-J

AU - Simon, M I

AU - Peyard, M

AU - Xie, Y-G

AU - Carter, N P

AU - Durbin, R

AU - Dumanski, J P

AU - Bentley, D R

AU - Dunham, I

PY - 1995/9/28

Y1 - 1995/9/28

N2 - We have constructed a high-resolution clone map of human chromosome 22 which integrates the available physical and genetic information, establishing a single consensus. The map consists of all classes of DNA landmarks ordered on 705 yeast artificial chromosomes (YACs) at an average landmark density of more than one per 70 kilobases. This map represents the practical limits of currently available YAC resources and provides the basis for determination of the entire gene content and genomic DNA sequence of human chromosome 22.

AB - We have constructed a high-resolution clone map of human chromosome 22 which integrates the available physical and genetic information, establishing a single consensus. The map consists of all classes of DNA landmarks ordered on 705 yeast artificial chromosomes (YACs) at an average landmark density of more than one per 70 kilobases. This map represents the practical limits of currently available YAC resources and provides the basis for determination of the entire gene content and genomic DNA sequence of human chromosome 22.

KW - Chromosome Mapping

KW - Chromosomes, Artificial, Yeast

KW - Chromosomes, Human, Pair 22

KW - Genetic Markers

KW - Humans

KW - Sequence Tagged Sites

UR - http://dx.doi.org/10.1038/377367a0

U2 - 10.1038/377367a0

DO - 10.1038/377367a0

M3 - Article

C2 - 7566101

SN - 0028-0836

VL - 377

SP - 367

EP - 379

JO - Nature

JF - Nature

IS - 6547 Suppl

ER -

A high-density YAC contig map of human chromosome 22

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