A hemicyanine based ratiometric fluorescence probe for mapping lysosomal pH during heat stroke in living cells

Luling Wu; Yang Wang; Tony D. James; Nengqin Jia; Chusen Huang

doi:10.1039/C8CC02330A

A hemicyanine based ratiometric fluorescence probe for mapping lysosomal pH during heat stroke in living cells

Luling Wu, Yang Wang, Tony D. James, Nengqin Jia, Chusen Huang

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51 Citations (SciVal)

Abstract

Heat stroke is a lethal condition which can cause dysfunction in the central nervous system, multi-organ damage and even death. However, there is still limited knowledge of the detailed mechanism about the roles of lysosomes in heat stroke due to lack of effective tools. Herein, we introduce our previously developed hemicyanine with a large D-π-A structure as the key fluorophore to develop a new fluorescent probe (CPY) for ratiometric mapping of lysosomal pH changes in live cells under a heat shock stimulus.

Original language	English
Pages (from-to)	5518-5521
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	44
Early online date	11 Apr 2018
DOIs	https://doi.org/10.1039/C8CC02330A
Publication status	Published - 4 Jun 2018

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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AU - Huang, Chusen

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AB - Heat stroke is a lethal condition which can cause dysfunction in the central nervous system, multi-organ damage and even death. However, there is still limited knowledge of the detailed mechanism about the roles of lysosomes in heat stroke due to lack of effective tools. Herein, we introduce our previously developed hemicyanine with a large D-π-A structure as the key fluorophore to develop a new fluorescent probe (CPY) for ratiometric mapping of lysosomal pH changes in live cells under a heat shock stimulus.

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A hemicyanine based ratiometric fluorescence probe for mapping lysosomal pH during heat stroke in living cells

Abstract

ASJC Scopus subject areas

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