A hemicyanine based ratiometric fluorescence probe for mapping lysosomal pH during heat stroke in living cells

Luling Wu, Yang Wang, Tony D. James, Nengqin Jia, Chusen Huang

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Heat stroke is a lethal condition which can cause dysfunction in the central nervous system, multi-organ damage and even death. However, there is still limited knowledge of the detailed mechanism about the roles of lysosomes in heat stroke due to lack of effective tools. Herein, we introduce our previously developed hemicyanine with a large D-π-A structure as the key fluorophore to develop a new fluorescent probe (CPY) for ratiometric mapping of lysosomal pH changes in live cells under a heat shock stimulus.

Original languageEnglish
Pages (from-to)5518-5521
Number of pages4
JournalChemical Communications
Volume54
Issue number44
Early online date11 Apr 2018
DOIs
Publication statusPublished - 4 Jun 2018

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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