A hemicyanine based ratiometric fluorescence probe for mapping lysosomal pH during heat stroke in living cells

Luling Wu, Yang Wang, Tony D. James, Nengqin Jia, Chusen Huang

Research output: Contribution to journalArticle

Abstract

Heat stroke is a lethal condition which can cause dysfunction in the central nervous system, multi-organ damage and even death. However, there is still limited knowledge of the detailed mechanism about the roles of lysosomes in heat stroke due to lack of effective tools. Herein, we introduce our previously developed hemicyanine with a large D-[small pi]-A structure as the key fluorophore to develop a new fluorescent probe (CPY) for ratiometric mapping of lysosomal pH changes in live cells under a heat shock stimulus.
LanguageEnglish
Pages5518-5521
Number of pages4
JournalChemical Communications
Volume54
Early online date11 Apr 2018
DOIs
StatusE-pub ahead of print - 11 Apr 2018

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Fluorescence
Cells
Fluorophores
Neurology
Fluorescent Dyes
tetramethylene hemicyanine
Hot Temperature

Cite this

A hemicyanine based ratiometric fluorescence probe for mapping lysosomal pH during heat stroke in living cells. / Wu, Luling; Wang, Yang; James, Tony D.; Jia, Nengqin; Huang, Chusen.

In: Chemical Communications, Vol. 54, 11.04.2018, p. 5518-5521.

Research output: Contribution to journalArticle

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