A hemicyanine-based fluorescent probe for ratiometric detection of ClO- and turn-on detection of viscosity and its imaging application in mitochondria of living cells and zebrafish

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Abstract

A water-soluble fluorescent probe 1 based on chromene-hemicyanine has been developed, that exhibits ratiometric fluorescent response toward hypochlorite (ClO-) with the LOD (0.082 μM), and “turn-on” response to viscosity changes. Due to low cytotoxicity and good biocompatibility, probe 1 used to monitor hypochlorous acid and viscosity in mitochondria of living cells and zebrafish.
Original languageEnglish
Article number133510
JournalSensors and Actuators B: Chemical
Volume383
Early online date13 Feb 2023
DOIs
Publication statusPublished - 15 May 2023

Bibliographical note

We acknowledge the Joint Program for Fostering Talents of National Natural Science Foundation of China and Henan Province (U1304202), State Scholarship Fund (CSC 201908410366), Henan Province Science and Technology Project (222300420523) (212102210646) and The Scientific Research Innovation Team of Xuchang University (2022CXTD001) for financial support. T. D. J. wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01).

Data availability
All data is supplied in the Supplementary Information

Keywords

  • Fluorescent probe
  • Hypochlorite
  • Imaging
  • Mitochondria targeting
  • Viscosity

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

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