A hemicyanine-based fluorescent probe for ratiometric detection of ClO- and turn-on detection of viscosity and its imaging application in mitochondria of living cells and zebrafish

Tony James

doi:10.1016/j.snb.2023.133510

A hemicyanine-based fluorescent probe for ratiometric detection of ClO- and turn-on detection of viscosity and its imaging application in mitochondria of living cells and zebrafish

Tony James

Research output: Contribution to journal › Article › peer-review

63 Citations (SciVal)

Abstract

A water-soluble fluorescent probe 1 based on chromene-hemicyanine has been developed, that exhibits ratiometric fluorescent response toward hypochlorite (ClO-) with the LOD (0.082 μM), and “turn-on” response to viscosity changes. Due to low cytotoxicity and good biocompatibility, probe 1 used to monitor hypochlorous acid and viscosity in mitochondria of living cells and zebrafish.

Original language	English
Article number	133510
Journal	Sensors and Actuators B: Chemical
Volume	383
Early online date	13 Feb 2023
DOIs	https://doi.org/10.1016/j.snb.2023.133510
Publication status	Published - 15 May 2023

Bibliographical note

We acknowledge the Joint Program for Fostering Talents of National Natural Science Foundation of China and Henan Province (U1304202), State Scholarship Fund (CSC 201908410366), Henan Province Science and Technology Project (222300420523) (212102210646) and The Scientific Research Innovation Team of Xuchang University (2022CXTD001) for financial support. T. D. J. wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01).

Data availability
All data is supplied in the Supplementary Information

Keywords

Fluorescent probe
Hypochlorite
Imaging
Mitochondria targeting
Viscosity

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

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10.1016/j.snb.2023.133510Licence: CC BY

Cite this

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title = "A hemicyanine-based fluorescent probe for ratiometric detection of ClO- and turn-on detection of viscosity and its imaging application in mitochondria of living cells and zebrafish",

abstract = "A water-soluble fluorescent probe 1 based on chromene-hemicyanine has been developed, that exhibits ratiometric fluorescent response toward hypochlorite (ClO-) with the LOD (0.082 μM), and “turn-on” response to viscosity changes. Due to low cytotoxicity and good biocompatibility, probe 1 used to monitor hypochlorous acid and viscosity in mitochondria of living cells and zebrafish.",

keywords = "Fluorescent probe, Hypochlorite, Imaging, Mitochondria targeting, Viscosity",

author = "Tony James",

note = "We acknowledge the Joint Program for Fostering Talents of National Natural Science Foundation of China and Henan Province (U1304202), State Scholarship Fund (CSC 201908410366), Henan Province Science and Technology Project (222300420523) (212102210646) and The Scientific Research Innovation Team of Xuchang University (2022CXTD001) for financial support. T. D. J. wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01). Data availability All data is supplied in the Supplementary Information ",

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N2 - A water-soluble fluorescent probe 1 based on chromene-hemicyanine has been developed, that exhibits ratiometric fluorescent response toward hypochlorite (ClO-) with the LOD (0.082 μM), and “turn-on” response to viscosity changes. Due to low cytotoxicity and good biocompatibility, probe 1 used to monitor hypochlorous acid and viscosity in mitochondria of living cells and zebrafish.

AB - A water-soluble fluorescent probe 1 based on chromene-hemicyanine has been developed, that exhibits ratiometric fluorescent response toward hypochlorite (ClO-) with the LOD (0.082 μM), and “turn-on” response to viscosity changes. Due to low cytotoxicity and good biocompatibility, probe 1 used to monitor hypochlorous acid and viscosity in mitochondria of living cells and zebrafish.

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KW - Hypochlorite

KW - Imaging

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KW - Viscosity

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A hemicyanine-based fluorescent probe for ratiometric detection of ClO- and turn-on detection of viscosity and its imaging application in mitochondria of living cells and zebrafish

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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