A hedonism hub in the human brain

George Zacharopoulos, T. M. Lancaster, T. Bracht, N. Ihssen, Gregory R. Maio, David E. J. Linden

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Human values are abstract ideals that motivate behavior. The motivational nature of human values raises the possibility that they might be underpinned by brain structures that are particularly involved in motivated behavior and reward processing. We hypothesized that variation in subcortical hubs of the reward system and their main connecting pathway, the supero-lateral medial forebrain bundle (slMFB) is associated with individual value orientation. We conducted Pearson’s correlation between the scores of 10 human values and the volumes of 14 subcortical structures and microstructural properties of the medial forebrain bundle in a sample of 87 participants, correcting for multiple comparisons (i.e.,190). We found a positive association between the value that people attach to hedonism and the volume of the left globus pallidus (GP).We then tested whether microstructural parameters (i.e., Fractional Anisotropy and Myelin Volume Fraction) of the slMFB, which connects with the GP, are also associated to hedonism and found a significant, albeit in an uncorrected level, positive association between the myelin volume fraction within the left slMFB and hedonism scores. This is the first study to elucidate the relationship between the importance people attach to the human value of hedonism and structural variation in reward-related subcortical brain regions.
Original languageEnglish
Pages (from-to)3921-3927
Number of pages7
JournalCerebral Cortex
Volume26
Issue number10
Early online date19 Sep 2016
DOIs
Publication statusPublished - 31 Oct 2016

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

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    Zacharopoulos, G., Lancaster, T. M., Bracht, T., Ihssen, N., Maio, G. R., & Linden, D. E. J. (2016). A hedonism hub in the human brain. Cerebral Cortex, 26(10), 3921-3927. https://doi.org/10.1093/cercor/bhw197