A grafting approach to preparing new biocompatible polymer materials with potential as tissue engineering scaffolds

Julian B Chaudhuri, John Davey, Gareth J Price

Research output: Contribution to journalArticle

Abstract

Thermally initiated and photo-initiated grafting methods are applied in prepg. polymer materials that will support tissue growth but also remain in situ to add mech. integrity. Materials based on medical grade polyurethane (PU) and poly(di-Me siloxane) (PDMS), which have been modified with poly(lactic-co-glycolic acid) or poly(e-caprolactone) (PCL), were studied. Cell culture expts. were conducted with human fibroblast and endothelial cells. Culture of fibroblast cells showed the native PDMS to be a better substrate for growth than the modified material although growth was very patchy. This shows that the grafting techniques were not applicable to PDMS materials. The lactide and glycolide modified PDMS showed poor cell attachment after seven days. A reasonably even coverage of cells can be obsd. in culture expts., demonstrating that the grafting process did not affect the ability to support cell growth. [on SciFinder (R)]
Original languageEnglish
Pages (from-to)814-815
Number of pages2
JournalPolymer Preprints (American Chemical Society, Division of Polymer Chemistry)
Volume45
Issue number1
Publication statusPublished - 2004

Keywords

  • grafting approach to prepg. new biocompatible polymer materials with potential as tissue engineering scaffolds)
  • USES (Uses) (caprolactone-based
  • USES (Uses) (grafting approach to prepg. new biocompatible polymer materials with potential as tissue engineering scaffolds)
  • Animal tissue culture
  • Human
  • Polymerization (graft
  • photochem.
  • BIOL (Biological study)
  • glycolide lactide PDMS polymer graft biomaterial
  • THU (Therapeutic use)
  • Polyurethanes Role
  • Prosthetic materials and Prosthetics (grafting approach to prepg. new biocompatible polymer materials with potential as tissue engineering scaffolds)
  • Contact angle
  • USES (Uses) (dilactone-based
  • Fibroblast
  • Cell proliferation
  • Polyesters Role

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