TY - JOUR
T1 - A frontal attention mechanism in the visual mismatch negativity
AU - Hedge, Craig
AU - Stothart, George
AU - Todd Jones, Jenna
AU - Rojas Frías, Priscila
AU - Magee, Kristopher Lundy
AU - Brooks, Jonathan C W
N1 - Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.
PY - 2015/10/15
Y1 - 2015/10/15
N2 - Automatic detection of environmental change is a core component of attention. The mismatch negativity (MMN), an electrophysiological marker of this mechanism, has been studied prominently in the auditory domain, with cortical generators identified in temporal and frontal regions. Here, we combined electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) to assess whether the underlying frontal regions associated with auditory change detection also play a role in visual change detection. Twenty healthy young adults completed a visual MMN task in separate EEG and fMRI sessions. Region of interest analyses were conducted on left and right middle frontal (MFG) and inferior frontal (IFG) gyri, i.e., the frontal areas identified as potential auditory MMN generators. A significant increase in activation was observed in the left IFG and MFG in response to blocks containing deviant stimuli. These findings suggest that a frontal mechanism is involved in the detection of change in the visual MMN. Our results support the notion that frontal mechanisms underlie attention switching, as measured via MMN, across multiple modalities.
AB - Automatic detection of environmental change is a core component of attention. The mismatch negativity (MMN), an electrophysiological marker of this mechanism, has been studied prominently in the auditory domain, with cortical generators identified in temporal and frontal regions. Here, we combined electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) to assess whether the underlying frontal regions associated with auditory change detection also play a role in visual change detection. Twenty healthy young adults completed a visual MMN task in separate EEG and fMRI sessions. Region of interest analyses were conducted on left and right middle frontal (MFG) and inferior frontal (IFG) gyri, i.e., the frontal areas identified as potential auditory MMN generators. A significant increase in activation was observed in the left IFG and MFG in response to blocks containing deviant stimuli. These findings suggest that a frontal mechanism is involved in the detection of change in the visual MMN. Our results support the notion that frontal mechanisms underlie attention switching, as measured via MMN, across multiple modalities.
KW - Adult
KW - Attention/physiology
KW - Brain Mapping
KW - Contingent Negative Variation/physiology
KW - Electroencephalography
KW - Evoked Potentials, Visual/physiology
KW - Female
KW - Frontal Lobe/blood supply
KW - Humans
KW - Image Processing, Computer-Assisted
KW - Magnetic Resonance Imaging
KW - Male
KW - Oxygen/blood
KW - Photic Stimulation
KW - Reaction Time
KW - Young Adult
UR - http://dx.doi.org/10.1016/j.bbr.2015.07.022
UR - http://dx.doi.org/10.1016/j.bbr.2015.07.022
U2 - 10.1016/j.bbr.2015.07.022
DO - 10.1016/j.bbr.2015.07.022
M3 - Article
C2 - 26183650
VL - 293
SP - 173
EP - 181
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
ER -