A fluorogenic 2D glycosheet for the simultaneous identification of human-and avian-receptor specificity in influenza viruses

Jin Xing Song, Xin Ying Tang, Dong Ming Zhou, Wenqing Zhang, Tony D. James, Xiao-Peng He, He Tian

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The switch in glycan-receptor specificity of influenza viruses may cause their interspecies transmission. However, tools that can simultaneous unveil the different receptor specificities of a single virus strain, in a homogeneous solution, have been elusive. Here we show a simple yet effective "2D glycosheet" that is capable of simultaneously identifying the human-and avian-glycan-receptor specificity of influenza viruses. Two fluorophores with different emission colors are coupled with avian-or human-glycan receptors. Then, the glycan-fluorophore conjugates with different receptors and emission colors are co-assembled on a 2D molybdenum disulfide platform, producing a duplexed, fluorogenic 2D glycosheet. While the system shows a single emission color with viruses containing a single receptor specificity, in the presence of a virus (H7N9) containing dual (human-and avian-) receptor specificity the system produces both emission colors. Interestingly, the use of graphene oxide and carbon nanotubes as the material substrate also produces dual emission with H7N9, thus enabling a new generation of low-dimensional glycomaterials for effectively probing the switch in receptor-specificity of influenza viruses.

Original languageEnglish
Pages (from-to)431-436
Number of pages6
JournalMaterials Horizons
Volume4
Issue number3
Early online date7 Mar 2017
DOIs
Publication statusPublished - 1 May 2017

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Viruses
Polysaccharides
Color
Fluorophores
Switches
Carbon Nanotubes
Graphite
Oxides
Graphene
Molybdenum
Carbon nanotubes
Substrates

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Process Chemistry and Technology
  • Electrical and Electronic Engineering

Cite this

A fluorogenic 2D glycosheet for the simultaneous identification of human-and avian-receptor specificity in influenza viruses. / Song, Jin Xing; Tang, Xin Ying; Zhou, Dong Ming; Zhang, Wenqing; James, Tony D.; He, Xiao-Peng; Tian, He.

In: Materials Horizons, Vol. 4, No. 3, 01.05.2017, p. 431-436.

Research output: Contribution to journalArticle

Song, Jin Xing ; Tang, Xin Ying ; Zhou, Dong Ming ; Zhang, Wenqing ; James, Tony D. ; He, Xiao-Peng ; Tian, He. / A fluorogenic 2D glycosheet for the simultaneous identification of human-and avian-receptor specificity in influenza viruses. In: Materials Horizons. 2017 ; Vol. 4, No. 3. pp. 431-436.
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