Abstract
The switch in glycan-receptor specificity of influenza viruses may cause their interspecies transmission. However, tools that can simultaneous unveil the different receptor specificities of a single virus strain, in a homogeneous solution, have been elusive. Here we show a simple yet effective "2D glycosheet" that is capable of simultaneously identifying the human-and avian-glycan-receptor specificity of influenza viruses. Two fluorophores with different emission colors are coupled with avian-or human-glycan receptors. Then, the glycan-fluorophore conjugates with different receptors and emission colors are co-assembled on a 2D molybdenum disulfide platform, producing a duplexed, fluorogenic 2D glycosheet. While the system shows a single emission color with viruses containing a single receptor specificity, in the presence of a virus (H7N9) containing dual (human-and avian-) receptor specificity the system produces both emission colors. Interestingly, the use of graphene oxide and carbon nanotubes as the material substrate also produces dual emission with H7N9, thus enabling a new generation of low-dimensional glycomaterials for effectively probing the switch in receptor-specificity of influenza viruses.
Original language | English |
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Pages (from-to) | 431-436 |
Number of pages | 6 |
Journal | Materials Horizons |
Volume | 4 |
Issue number | 3 |
Early online date | 7 Mar 2017 |
DOIs | |
Publication status | Published - 1 May 2017 |
ASJC Scopus subject areas
- General Materials Science
- Mechanics of Materials
- Process Chemistry and Technology
- Electrical and Electronic Engineering
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Tony James
- Department of Chemistry - Professor
- Centre for Sustainable Chemical Technologies (CSCT)
- Centre for Bioengineering & Biomedical Technologies (CBio)
- Institute of Sustainability and Climate Change
Person: Research & Teaching, Affiliate staff